Abstract:

Objective To investigate the changes and the correlations of ferritin,hemoglobin（Hb） and thyroid hormones in different trimester pregnant women. Methods A total of 561 pregnant women at different trimesters receiving the first antenatal care were enrolled,and they were classified into 3 groups according to different trimesters,including the first trimester（200 cases）,the second trimester（180 cases） and the third trimester（181 cases）. Totally,180 healthy non-pregnant women were enrolled as control group. The levels of serum thyroid hormones,such as triiodothyronine（T₃）,thyroxine（T₄）,free triiodothyronine（FT₃）,free thyroxine（FT₄）,thyroid stimulating hormone（TSH）, were determined,and ferritin and Hb were determined as well. Statistical analysis was performed. Results Compared with control group,the levels of ferritin in the 3 groups were lower（P<0.05）. The levels of Hb in the second trimester and the third trimester groups were lower（P<0.05）,but there was no statistical significance between the first trimester and control groups（P>0.05）. The levels of ferritin and Hb were decreased with the progress of pregnancy,and there was statistical significance between the first trimester and the third trimester groups（P<0.05）. Pearson correlation analysis showed that Hb was positively correlated with FT₃ and FT₄ in the first trimester（r=0.265 and 0.180,P=0.000 and 0.004,respectively）,and it was positively correlated with FT₃ in the third trimester（r=0.556,P=0.005）. Serum level of ferritin was correlated with FT₃ and FT₄ in the third trimester（r=0.502 and 0.494,P=0.013 and 0.014,respectively）. Conclusions The decreasing of serum ferritin and Hb may lead to the low levels of FT₃ and FT₄. Thyroid dysfunction in pregnant women is closely related to iron deficiency.

Key words: Ferritin, Hemoglobin, Thyroid hormone, Pregnancy