Abstract:

Objective To investigate the changes of blood lipid levels among healthy pregnant women,and to define appropriate blood lipid levels for healthy pregnant women. Methods A total of 2 124 healthy pregnant women were enrolled,which were classified into 3 groups according to gestational weeks,including early pregnancy group（276 cases）,middle pregnancy group（961 cases） and late pregnancy group（887 cases）. All the subjects were classified into 2 groups according to ages,including advanced age group（478 cases） and appropriate age group（1 646 cases）. A total of 712 non-pregnant women were enrolled as control group. The levels of triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein A1（apo A1） and apolipoprotein B（apo B） were determined. The appropriate blood lipid levels for healthy pregnant women were defined by percentile mothod [the 2.5th percentile（P_2.5） and the 97.5th percentile（P_97.5）]. Results Except for TG in early pregnancy group,the other blood lipid parameters in early,middle and late pregnancy groups were higher than those in control group（P<0.05）. All the blood lipid parameters in middle and late pregnancy groups were higher than those in early pregnancy group（P<0.05）. All the blood lipid parameters in late pregnancy group were higher than those in middle pregnancy group（P<0.05）. Gestational week-specific appropriate blood lipid levels of TC,HDL-C,LDL-C,apo A1 and apo B had been defined by percentile method. Gestational week-specific and age-specific appropriate levels of TG had been also defined by percentile method. Conclusions Appropriate blood lipid levels of healthy pregnant women in Zhengzhou have been defined,in order to provide a reference for monitoring blood lipid levels during pregnancy.

Key words: Blood lipid, Appropriate level, Pregnancy, Gestational week