Laboratory Medicine ›› 2020, Vol. 35 ›› Issue (1): 1-5.DOI: 10.3969/j.issn.1673-8640.2020.01.001
Received:
2018-11-18
Online:
2020-01-30
Published:
2020-02-28
CLC Number:
HONG Ping, WANG Peichang. Correlation between biochemical parameters and apolipoprotein E genotypes among inpatients with late-onset Alzheimer’s disease in Beijing[J]. Laboratory Medicine, 2020, 35(1): 1-5.
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2020.01.001
组别 | 例数 | 基因型 | 等位基因 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
E2/2 | E2/3 | E3/3 | E3/4 | E2/4 | E4/4 | ε2 | ε3 | ε4 | |||
AD组 | 150 | 8 (5.33) | 18(12.00) | 21(14.00) | 61(40.67) | 23(15.33) | 19(12.67) | 57(19.00) | 121(40.33) | 122(40.67) | |
正常对照组 | 150 | 0 (0) | 32(21.33) | 108(72.00) | 8 (5.33) | 2 (1.33) | 0 (0) | 34(11.33) | 256(85.33) | 10 (3.33) | |
χ2值 | 6.29 | 4.06 | 100.58 | 50.89 | 17.46 | 18.21 | 6.27 | 128.15 | 119.67 | ||
P值 | >0.05 | <0.05 | <0.05 | <0.01 | <0.01 | >0.05 | >0.05 | <0.05 | <0.01 |
组别 | 例数 | 基因型 | 等位基因 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
E2/2 | E2/3 | E3/3 | E3/4 | E2/4 | E4/4 | ε2 | ε3 | ε4 | |||
AD组 | 150 | 8 (5.33) | 18(12.00) | 21(14.00) | 61(40.67) | 23(15.33) | 19(12.67) | 57(19.00) | 121(40.33) | 122(40.67) | |
正常对照组 | 150 | 0 (0) | 32(21.33) | 108(72.00) | 8 (5.33) | 2 (1.33) | 0 (0) | 34(11.33) | 256(85.33) | 10 (3.33) | |
χ2值 | 6.29 | 4.06 | 100.58 | 50.89 | 17.46 | 18.21 | 6.27 | 128.15 | 119.67 | ||
P值 | >0.05 | <0.05 | <0.05 | <0.01 | <0.01 | >0.05 | >0.05 | <0.05 | <0.01 |
组别 | 例数 | TC/ (mmol/L) | TG/ (mmol/L) | LDL-C/ (mmol/L) | sd-LDL-C/ (mmol/L) | HDL-C/ (mmol/L) | apo A/ (g/L) | apo B/ (g/L) | Lp(a)/(mg/L) |
---|---|---|---|---|---|---|---|---|---|
AD组 | 150 | 4.53±0.85 | 1.35±0.13 | 3.57±0.33 | 1.13±0.11 | 1.14±0.11 | 1.27±0.16 | 1.05±0.11 | 282.63±199.47 |
正常对照组 | 150 | 3.76±0.87 | 1.32±0.15 | 2.38±0.19 | 0.78±0.05 | 1.62±0.27 | 1.35±0.15 | 0.98±0.08 | 255.41±183.34 |
t值 | 4.57 | -0.04 | 4.63 | 4.51 | -4.09 | -0.04 | 0.46 | 0.23 | |
P值 | <0.01 | >0.05 | <0.01 | <0.01 | <0.01 | >0.05 | >0.05 | >0.05 |
组别 | 例数 | TC/ (mmol/L) | TG/ (mmol/L) | LDL-C/ (mmol/L) | sd-LDL-C/ (mmol/L) | HDL-C/ (mmol/L) | apo A/ (g/L) | apo B/ (g/L) | Lp(a)/(mg/L) |
---|---|---|---|---|---|---|---|---|---|
AD组 | 150 | 4.53±0.85 | 1.35±0.13 | 3.57±0.33 | 1.13±0.11 | 1.14±0.11 | 1.27±0.16 | 1.05±0.11 | 282.63±199.47 |
正常对照组 | 150 | 3.76±0.87 | 1.32±0.15 | 2.38±0.19 | 0.78±0.05 | 1.62±0.27 | 1.35±0.15 | 0.98±0.08 | 255.41±183.34 |
t值 | 4.57 | -0.04 | 4.63 | 4.51 | -4.09 | -0.04 | 0.46 | 0.23 | |
P值 | <0.01 | >0.05 | <0.01 | <0.01 | <0.01 | >0.05 | >0.05 | >0.05 |
apo E 表型 | 例数 | TC/ (mmol/L) | TG/ (mmol/L) | LDL-C/ (mmol/L) | sd-LDL-C/ (mmol/L) | HDL-C/ (mmol/L) | apo A/ (g/L) | apo B/ (g/L) | Lp(a)/ (mg/L) |
---|---|---|---|---|---|---|---|---|---|
ε2 | 57 | 3.45±0.31 | 2.53±0.51 | 3.02±0.32 | 1.21±0.12 | 1.08±0.11 | 1.22±0.13 | 1.08±0.10 | 297.63±193.58 |
ε3 | 121 | 4.18±0.71* | 2.28±0.47 | 3.61±0.41* | 0.98±0.09 | 1.21±0.12 | 1.31±0.15 | 1.02±0.09 | 275.32±179.87 |
ε4 | 122 | 4.89±0.52*# | 2.49±0.61 | 4.08±0.28*# | 1.16±0.10 | 1.12±0.11 | 1.29±0.16 | 1.04±0.11 | 287.65±189.43 |
apo E 表型 | 例数 | TC/ (mmol/L) | TG/ (mmol/L) | LDL-C/ (mmol/L) | sd-LDL-C/ (mmol/L) | HDL-C/ (mmol/L) | apo A/ (g/L) | apo B/ (g/L) | Lp(a)/ (mg/L) |
---|---|---|---|---|---|---|---|---|---|
ε2 | 57 | 3.45±0.31 | 2.53±0.51 | 3.02±0.32 | 1.21±0.12 | 1.08±0.11 | 1.22±0.13 | 1.08±0.10 | 297.63±193.58 |
ε3 | 121 | 4.18±0.71* | 2.28±0.47 | 3.61±0.41* | 0.98±0.09 | 1.21±0.12 | 1.31±0.15 | 1.02±0.09 | 275.32±179.87 |
ε4 | 122 | 4.89±0.52*# | 2.49±0.61 | 4.08±0.28*# | 1.16±0.10 | 1.12±0.11 | 1.29±0.16 | 1.04±0.11 | 287.65±189.43 |
apo E表型 | 例数 | TC/ (mmol/L) | TG/ (mmol/L) | LDL-C/(mmol/L) | sd-LDL-C/(mmol/L) | HDL-C/(mmol/L) | apo A/ (g/L) | apo B/ (g/L) | Lp(a)/ (mg/L) |
---|---|---|---|---|---|---|---|---|---|
ε2 | 34 | 3.81±0.82 | 1.22±0.12 | 2.22±0.18 | 0.79±0.05 | 1.60±0.25 | 1.38±0.16 | 0.96±0.08 | 251.47±188.66 |
ε3 | 256 | 3.63±0.89 | 1.31±0.11 | 2.31±0.20 | 0.75±0.04 | 1.55±0.23 | 1.31±0.13 | 1.03±0.09 | 264.35±179.87 |
ε4 | 10 | 3.71±0.79 | 1.24±0.12 | 2.82±0.15* | 0.77±0.05 | 1.69±0.29 | 1.34±0.15 | 0.97±0.07 | 275.02±180.22 |
apo E表型 | 例数 | TC/ (mmol/L) | TG/ (mmol/L) | LDL-C/(mmol/L) | sd-LDL-C/(mmol/L) | HDL-C/(mmol/L) | apo A/ (g/L) | apo B/ (g/L) | Lp(a)/ (mg/L) |
---|---|---|---|---|---|---|---|---|---|
ε2 | 34 | 3.81±0.82 | 1.22±0.12 | 2.22±0.18 | 0.79±0.05 | 1.60±0.25 | 1.38±0.16 | 0.96±0.08 | 251.47±188.66 |
ε3 | 256 | 3.63±0.89 | 1.31±0.11 | 2.31±0.20 | 0.75±0.04 | 1.55±0.23 | 1.31±0.13 | 1.03±0.09 | 264.35±179.87 |
ε4 | 10 | 3.71±0.79 | 1.24±0.12 | 2.82±0.15* | 0.77±0.05 | 1.69±0.29 | 1.34±0.15 | 0.97±0.07 | 275.02±180.22 |
项目 | 回归系数 | 标准误 | P值 | OR值(95%CI) |
---|---|---|---|---|
ε4等位基因 | 2.671 | 0.384 | 0.000 | 14.454(5.793~16.368) |
LDL-C | 1.762 | 0.729 | 0.012 | 5.824(2.582~7.973) |
HDL-C | -3.926 | 0.692 | 0.005 | 0.020(0.006~0.352) |
项目 | 回归系数 | 标准误 | P值 | OR值(95%CI) |
---|---|---|---|---|
ε4等位基因 | 2.671 | 0.384 | 0.000 | 14.454(5.793~16.368) |
LDL-C | 1.762 | 0.729 | 0.012 | 5.824(2.582~7.973) |
HDL-C | -3.926 | 0.692 | 0.005 | 0.020(0.006~0.352) |
[1] | JACK C R,Jr,ALBERT M S,KNOPMAN D S,et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease[J]. Alzheimers Dement,2011,7(3):257-262. |
[2] | DAY G S,MUSIEK E S,ROE C M,et al.Phenotypic similarities between late-onset autosomal dominant and sporadic Alzheimer disease:a single-family case-control study[J]. JAMA Neurol,2016,73(9):1125-1132. |
[3] | BANECKA-MAJKUTEWICZ Z,SAWUA W,KADZISKI L,et al.Homocysteine,heat shock proteins,genistein and vitamins in ischemic stroke-pathogenic and therapeutic implications[J]. Acta Biochim Pol,2012,59(4):495-499. |
[4] | MCKHANN G,DRACHMAN D,FOLSTEIN M,et al.Clinical diagnosis of Alzheimer’s disease:report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease[J]. Neurology,1984,34(7):939-944. |
[5] | LIU M,ZHANG W,LI X,et al.Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice[J]. Biochem Biophys Res Commun,2016,469(3):456-462. |
[6] | DAS S,KAUL S,JYOTHY A,et al.Association of APOE(E2,E3 and E4) gene variants and lipid levels in ischemic stroke,its subtypes and hemorrhagic stroke in a South Indian population[J]. Neurosci Lett,2016,628:136-141. |
[7] | AFROZE D,YOUSUF A,TRAMBOO N A,et al.Apo E gene polymorphism and its relationship with coronary artery disease in ethnic Kashmiri population[J]. Clin Exp Med,2015,16(4):551-556. |
[8] | ZHAO X S,WU Q,PENG J,et al.Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression[J]. Mol Med Rep,2017,15(2):712-718. |
[9] | JANG D K,HUH P W,LEE K S.Association of apolipoprotein E gene polymorphism with small-vessel lesions and stroke type in moyamoya disease:a preliminary study[J]. J Neurosurg,2016,124(6):1738-1745. |
[10] | 张彦红,朱磊,郑德俊,等. 载脂蛋白E基因多态性与不同性别和病因分型脑梗死患者的关系[J]. 中国脑血管病杂志,2014,11(6):305-310. |
[11] | 陈煜森,许志恩,赵斌,等. ApoE基因多态性与阿尔茨海默病的相关性研究[J]. 神经疾病与精神卫生,2006,6(2):89-91. |
[12] | TAO Q Q,CHEN Y,LIU Z J,et al.Associations between apolipoprotein E genotypes and serum levels of glucose,cholesterol,and triglycerides in a cognitively normal aging Han Chinese population[J]. Clin Interv Aging,2014,9:1063-1067. |
[13] | RAYGANI A,RAHIMI Z,KHARAZI H,et al.Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer’s disease[J]. Neurosci Lett,2006,408(1):68-72. |
[14] | 李冬梅,王玉明,杨家义,等. APOE基因多态性与阿尔茨海默病的相关性研究[J]. 现代检验医学杂志,2008,23(2):20-23. |
[15] | BA M,KONG M,LI X,et al.Is Apo E ε 4 a good biomarker for amyloid pathology in late onset Alzheimer’s disease?[J]. Transl Neurodegener,2016,5:20. |
[16] | KEENEY J T,IBRAHIMI S,ZHAO L.Human apoE isoforms differentially modulate glucose and amyloid metabolic pathways in female brain:evidence of the mechanism of neuroprotection by apo E2 and implications for Alzheimer’s disease prevention and early intervention[J]. J Alzheimers Dis,2015,48(2):411-424. |
[17] | LARSON I A,ORDOVAS J M,DELUCA C,et al.Association of apolipoprotein(Apo)E genotype with plasma apo E levels[J]. Atherosclerosis,2000,148(2):327-335. |
[18] | BANGEN K J,HIMALI J J,BEISER A S,et al.Interaction between midlife blood glucose and APOE genotype predicts later Alzheimer’s disease pathology[J]. J Alzheimers Dis,2016,53(4):1553-1562. |
[1] | PENG Shouning, DENG Weicong, FU Yanbo, WU Yanni. Relationship between KCNH2 and CACNA1C gene polymorphisms and cognitive function in patients with schizophrenia [J]. Laboratory Medicine, 2023, 38(8): 742-747. |
[2] | MA Jianguo, LI Hongchun. Correlation between blood lipid levels and cardiac function indexes in patients with coronary heart disease [J]. Laboratory Medicine, 2023, 38(7): 659-664. |
[3] | ZHANG Xuming, YIN Weiming, GAO Jing. Correlation of UGT1A1 gene polymorphism with pregnancy complications and adverse pregnancy outcomes among gestational hypothyroidism patients in Shenzhen Bao'an area [J]. Laboratory Medicine, 2023, 38(7): 665-668. |
[4] | JIN Suli, ZHAO Jing, ZHANG Jie, HOU Xuening, FANG Yanchao, YANG Li, MI Yujing. Relationship between thyroid hormones and bile acid subfractions and blood lipids in Graves' disease patients [J]. Laboratory Medicine, 2023, 38(6): 563-568. |
[5] | WU Youhong, SONG Yunxiao, ZHU Yong, GE Wen, BIAN Xiaobo, YUAN Wenhua, ZHAO Zhiyun. Role of blood lipid levels in assessment of coronary artery stenosis and its treatment in patients with coronary heart disease [J]. Laboratory Medicine, 2023, 38(6): 584-589. |
[6] | LI Mu, GONG Dongliang, XU Liming, PENG Rong. Relationship of XPC rs2228000 polymorphisms and breast cancer [J]. Laboratory Medicine, 2023, 38(3): 235-239. |
[7] | NIE Tian, RAN Zihan, JIN Lei. Research progress on the relationship between interleukin gene polymorphisms and gastric cancer [J]. Laboratory Medicine, 2022, 37(9): 882-886. |
[8] | SHEN Jianguo, LI Tingting, SONG Yunxiao, BIAN Xiaobo, ZHANG Linlin, JIN Xiaoling. Clinical role of blood lipid in brittle fracture elderly patients with osteoporosis [J]. Laboratory Medicine, 2022, 37(6): 535-538. |
[9] | WANG Lingling, REN Chunli. Correlation of MTHFR gene C677T polymorphism and blood lipid levels with GDM [J]. Laboratory Medicine, 2022, 37(6): 543-546. |
[10] | WANG Shan, XU Minyi, WANG Wei, JIANG Mingming, LU Pei, XIONG Zhongbo, WANG Lei. Clinical value of MTHFR gene C677T polymorphism determination in patients with H-type hypertension [J]. Laboratory Medicine, 2022, 37(11): 1012-1016. |
[11] | PENG Yanjun, HAN Xuejing, TANG Hongxia, CHEN Junmeng, JIA Kegang. Correlation between nuclear magnetic resonance spectroscopy and traditional biochemical determination methods analyzer for determining blood lipid [J]. Laboratory Medicine, 2021, 36(7): 733-737. |
[12] | DAI Yanpeng, YUAN Enwu, LIU Junjie, LI Yushan, WANG Quanxian. Analysis of the appropriate levels of blood lipid among healthy pregnant women in Zhengzhou [J]. Laboratory Medicine, 2021, 36(6): 604-608. |
[13] | LI Jing, QUAN Hui, ZENG Zhirong, WEI Yi. Establishment of the reference interval of small and dense low-density lipoprotein cholesterol in apparently healthy adults in Chengdu [J]. Laboratory Medicine, 2021, 36(6): 609-614. |
[14] | WANG Linlin, FAN Jun, YE Chenyu, YING Chunmei. Correlation between blood lipid and carotid atherosclerotic plaque in elderly patients with coronary heart disease [J]. Laboratory Medicine, 2021, 36(6): 618-622. |
[15] | KONG Fanbin, YUAN Yong, JI Yong, LI Zheng, CHEN Qi, WU Xiaoming, GAO Hui. Correlation between serum retinol binding protein 4,homocysteine and blood lipid with atherosclerosis [J]. Laboratory Medicine, 2021, 36(5): 467-470. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||