Abstract:

Objective To investigate the relationship between thyroid hormones and bile acid subfractions and blood lipids in patients with Graves' disease（GD）. Methods Totally，43 patients with GD in the First Hospital of Hebei Medical University from October 2021 to February 2022（GD group）were enrolled，and 36 healthy subjects were used as healthy control group. Six primary bile acids [cholic acid（CA），chenodesoxycholic acid（CDCA），glycocholic acid（GCA），glycocholic chenodesoxycholic acid（GCDCA），taurocholic acid（TCA），taurochenodeoxycholic acid（TCDCA）]，nine secondary bile acids [deoxycholic acid（DCA），ursodeoxycholic acid（UDCA），lithocholic acid（LCA），glycodeoxycholic acid（GDCA），glyco-ursodeoxycholic acid（GUDCA），glycine cholic acid（GLCA），tauro-deoxycholic acid（TDCA），taurocholic acid（TLCA），tauro-ursodeoxycholic acid（TUDCA）]，thyroid function [free triiodothyronine（FT₃），free thyroxine（FT₄），high-sensitivity thyroid stimulating hormone（hs-TSH）] and biochemical parameters [fasting blood glucose（FBG），triglyceride（TG），total cholesterol（TC），high-density lipoprotein cholesterol（HDL-C），low-density lipoprotein cholesterol（LDL-C），aspartate aminotransferase（AST），alanine aminotransferase（ALT）] were determined. Results The differences in hs-TSH，FT₃，FT₄，TC，HDL-C and LDL-C levels between GD group and healthy control group were statistically significant（P<0.05），and the differences in FBG，AST，ALT and TG levels were not statistically significant（P>0.05）. Compared with healthy control group，DCA，UDCA，GDCA，GUDCA and TUDCA were lower in GD group（P<0.05），and the differences in LCA，GLCA，TDCA，TLCA，CA，CDCA，GCA，GCDCA，TCA and TCDCA were not statistically significant（P>0.05）. Conclusions The patients with GD have altered concentrations of some bile acid subfractions and blood lipids in serum.

Key words: Bile acid profile, Ursodeoxycholic acid, Deoxycholic acid, Blood lipid, Thyroid function, Graves' disease