Role of small and dense low-density lipoprotein cholesterol in cardiovascular and cerebrovascular diseases

doi:10.3969/j.issn.1673-8640.2019.01.04

Abstract

Abstract:

Objective To investigate the role of small and dense low-density lipoprotein cholesterol （sd-LDL-C） in 4 kinds of cardiovascular and cerebrovascular diseases [coronary heart disease,type 2 diabetes mellitus（T2DM）,hypertension and cerebral stroke]. Methods A total of 50 patients with hypertension,90 patients with T2DM,129 patients with coronary heart disease and 110 patients with cerebral stroke were enrolled as disease group. Totally,104 healthy subjects were enrolled as healthy control group. The levels of blood glucose （Glu）, apolipoprotein A1（apo A1）,apolipoprotein B（apo B）,apolipoprotein E（apo E）, total cholesterol（TC）,triglyceride（TG）,homocysteine（Hcy）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C） and sd-LDL-C were determined in disease and control groups. The relationship was evaluated by Spearman correlation analysis. Results The apo B,TC,Glu and sd-LDL-C levels in hypertension group were higher than those in control group （P<0.05）. The TG and Hcy levels in cerebral stroke group were higher than those in control group （P<0.05）,and the apo A1,apo B,apo E and LDL-C levels were lower （P<0.05）. The TC,Glu,TG,Hcy and sd-LDL-C levels in T2DM group were higher than those in control group （P<0.05）,and the apo A1 level was lower （P<0.05）. The TC,Glu,TG and Hcy levels of coronary heart disease group were higher than those in control group （P<0.05）,and the apo A1 level was lower than that in control group （P<0.05）. The sd-LDL-C level in coronary heart disease group was positively correlated with apo A1,apo B,apo E,TC and LDL-C （r=0.372,0.316,0.248,0.718 and 0.316,P<0.05）,and it was negatively correlated with HDL-C（r=-0.218,P<0.05）. The sd-LDL-C level in T2DM group was positively correlated with apo A1,apo B,apo E,TC,TG and LDL-C（r=0.243,0.779,0.416,0.616,0.614 and 0.678,P<0.05）. The sd-LDL-C level in hypertension group was positively correlated with TC,TG and LDL-C（r=0.623,0.756 and 0.699,P<0.05）,and it was negatively correlated with HDL-C（r=-0.355,P<0.05）. The sd-LDL-C level in cerebral stroke group was positively correlated with apo A1,apo E and TG（r=0.398,0.117 and 0.271,P<0.05）. Conclusions Sd-LDL-C levels in T2DM and hypertension groups are increased,and the level of sd-LDL-C plays a role in cardiovascular and cerebrovascular diseases.

Key words: Small and dense low-density lipoprotein cholesterol, Blood lipid, Cardiovascular and cerebrovascular diseases

CLC Number:

R446.1

WANG Shengkui, ZHOU Jun. Role of small and dense low-density lipoprotein cholesterol in cardiovascular and cerebrovascular diseases[J]. Laboratory Medicine, 2019, 34(1): 19-22.

Figures/Tables 1

References 10

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组别	例数	apo A1（g/L）	apo B（g/L）	apo E（mg/L）		TC（mmol/L）		TG（mmol/L）	HDL-C（mmol/L）
高血压组	50	1.24±0.27	1.01±0.27^*	46（36~51）^*		4.55±0.43^*		1.08（0.69~1.44）	1.31±0.34
脑梗死组	110	1.04±0.23^*	0.84±0.21^*	39（30~45）^*		4.42±0.83		1.46（0.93~1.68）^*	1.28±0.39
T2DM组	90	1.15±0.25^*	0.92±0.27	41（35~46）		4.65±1.06^*		1.50（1.13~2.26）^*	1.34±0.37
冠心病组	129	1.15±0.25^*	0.92±0.28	41（32~45）		4.65±1.26^*		1.50（0.86~1.61）^*	1.34±0.33
正常对照组	104	1.22±0.25	0.93±0.21	46（25~57）		4.38±0.41		1.03（0.25~1.78）	1.30±0.34
组别	LDL-C（mmol/L）		sd-LDL-C（mmol/L）		Glu（mmol/L）		Hcy（mol/L）
高血压组	2.63（2.39~2.96）		0.69（0.46~1.17）^*		7.14（5.40~7.85）^*		15.2（10.3~16.3）
脑梗死组	2.10（2.02~2.96）^*		0.52（0.36~0.84）		6.11（5.00~6.83）		18.8（12.5~24.1）^*
T2DM组	2.73（2.30~3.46）		0.58（0.38~1.09）^*		6.77（6.25~10.71）^*		17.1（10.6~15.9）^*
冠心病组	2.73（1.87~3.51）		0.51（0.31~0.82）		6.76（4.81~6.52）^*		17.1（13.6~22.9）^*
正常对照组	2.73（2.11~3.34）		0.48（0.36~0.62）		6.00（3.40~7.70）		14.12（7.96~21.12）

组别	例数	apo A1（g/L）	apo B（g/L）	apo E（mg/L）		TC（mmol/L）		TG（mmol/L）	HDL-C（mmol/L）
高血压组	50	1.24±0.27	1.01±0.27^*	46（36~51）^*		4.55±0.43^*		1.08（0.69~1.44）	1.31±0.34
脑梗死组	110	1.04±0.23^*	0.84±0.21^*	39（30~45）^*		4.42±0.83		1.46（0.93~1.68）^*	1.28±0.39
T2DM组	90	1.15±0.25^*	0.92±0.27	41（35~46）		4.65±1.06^*		1.50（1.13~2.26）^*	1.34±0.37
冠心病组	129	1.15±0.25^*	0.92±0.28	41（32~45）		4.65±1.26^*		1.50（0.86~1.61）^*	1.34±0.33
正常对照组	104	1.22±0.25	0.93±0.21	46（25~57）		4.38±0.41		1.03（0.25~1.78）	1.30±0.34
组别	LDL-C（mmol/L）		sd-LDL-C（mmol/L）		Glu（mmol/L）		Hcy（mol/L）
高血压组	2.63（2.39~2.96）		0.69（0.46~1.17）^*		7.14（5.40~7.85）^*		15.2（10.3~16.3）
脑梗死组	2.10（2.02~2.96）^*		0.52（0.36~0.84）		6.11（5.00~6.83）		18.8（12.5~24.1）^*
T2DM组	2.73（2.30~3.46）		0.58（0.38~1.09）^*		6.77（6.25~10.71）^*		17.1（10.6~15.9）^*
冠心病组	2.73（1.87~3.51）		0.51（0.31~0.82）		6.76（4.81~6.52）^*		17.1（13.6~22.9）^*
正常对照组	2.73（2.11~3.34）		0.48（0.36~0.62）		6.00（3.40~7.70）		14.12（7.96~21.12）

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