Abstract:

Objective To analyze the correlation between glycolipid metabolism and lipopolysaccharide（LPS） in patients with Alzheimer's disease（AD）. Methods Blood lipids [total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C） and apolipoprotein E（apo E）],fasting blood glucose（FPG）,fasting insulin（FINS） and gut barrier function indicators（D-lactic acid and LPS） were determined in 38 patients with severe dementia（dementia group）,37 patients with mild cognitive impairment（MCI）（MCI group） and 40 geriatric healthy subjects（healthy control group）. Homeostasis model assessment fo insulin resistance（HOMA-IR） was calculated. Results The FPG,FINS,HOMA-IR and TC levels of dementia group and MCI group were higher than those of healthy control group（P<0.01）,and serum HDL-C level was lower（P<0.01）. Serum TG level in MCI group was higher than that in healthy control group（P<0.05）. The difference of FPG,FINS and HOMA-IR between dementia group and MCI group had statistical significance（P<0.01）. Serum levels of D-lactic acid and LPS in dementia group were higher than those in healthy control group（P<0.000 1）. Pearson correlation analysis showed a positive correlation between LPS and TC in dementia group（r=0.68,P<0.05）. Logistic regression analysis showed that increased TC and FPG were MCI and dementia's risk factors,and increased HDL-C was a protective factor（P<0.05）. Increased LPS was a risk factor for dementia（P<0.05）. Conclusions Abnormal glycolipid metabolism in AD patients may be associated with impaired gut barrier.

Key words: Blood lipid, Blood glucose, Lipopolysaccharide, Alzheimer's disease