Laboratory Medicine ›› 2021, Vol. 36 ›› Issue (3): 285-291.DOI: 10.3969/j.issn.1673-8640.2021.03.011
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CHEN Xingyu, DONG Feifei
Received:
2019-11-04
Online:
2021-03-30
Published:
2021-03-30
CLC Number:
CHEN Xingyu, DONG Feifei. Correlation between fasting blood glucose variability parameters and painful diabetic peripheral neuropathy[J]. Laboratory Medicine, 2021, 36(3): 285-291.
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URL: https://www.shjyyx.com/EN/10.3969/j.issn.1673-8640.2021.03.011
组别 | 例数 | 年龄/岁 | 性别 | BMI/ (kg/m2) | 糖尿病 病程/年 | 吸烟史/ 例 | 家族史/ 例 | |
---|---|---|---|---|---|---|---|---|
男/例 | 女/例 | |||||||
正常对照组 | 42 | 58.19±8.63 | 26 | 16 | 22.74±1.04 | 16 | 4 | |
单纯T2DM组 | 63 | 59.51±8.88 | 41 | 22 | 25.97±1.09* | 5.79±1.85 | 26 | 9 |
NPDPN组 | 77 | 58.91±9.01 | 55 | 22 | 26.76±1.19* | 10.11±2.17## | 33 | 10 |
PDPN组 | 58 | 58.12±8.96 | 39 | 19 | 26.03±1.27* | 10.29±2.09## | 24 | 8 |
统计值 | 1.023 | 1.284 | 7.692 | 9.024 | 0.255 | 0.575 | ||
P值 | 0.872 | 0.733 | 0.016 | 0.006 | 0.968 | 0.902 | ||
组别 | FBG/ (mmol/L) | 2 h PG/(mmol/L) | TG/ (mmol/L) | TC/ (mmol/L) | LDL-C/(mmol/L) | HDL-C/(mmol/L) | HbA1c/% | |
正常对照组 | 5.23±0.62 | 6.48±0.63 | 1.53±0.28 | 4.57±0.68 | 2.19±0.65 | 1.34±0.27 | 5.27±0.57 | |
单纯T2DM组 | 7.69±0.86* | 8.27±0.84* | 1.88±0.31 | 4.62±0.73 | 2.64±0.71 | 0.96±0.28* | 7.40±0.62* | |
NPDPN组 | 8.22±0.91** | 9.18±0.81* | 1.92±0.37* | 4.82±0.79 | 2.69±0.73 | 0.86±0.31* | 7.61±0.71* | |
PDPN组 | 9.45±0.87**#△ | 9.74±1.96** | 2.62±0.52**# | 4.81±1.04 | 3.03±0.97 | 0.77±0.39**# | 8.73±0.74**#△ | |
统计值 | 11.352 | 9.291 | 10.807 | 0.996 | 7.656 | 11.882 | 12.754 | |
P值 | 0.001 | 0.006 | <0.001 | 0.742 | 0.054 | 0.005 | <0.001 | |
组别 | BDNF/(ng/mL) | HMGB1/(ng/mL) | MMCV/(m/s) | PMCV/(m/s) | MSCV/(m/s) | PSCV/(m/s) | ||
正常对照组 | 10.44±1.19 | 28.47±2.87 | 49.65±5.01 | 51.30±5.63 | 55.94±6.95 | 54.61±4.86 | ||
单纯T2DM组 | 8.09±0.86* | 35.41±3.49* | 43.57±6.55* | 43.87±6.11* | 47.58±6.24* | 46.52±5.81* | ||
NPDPN组 | 7.13±0.81** | 41.28±3.87**# | 38.47±5.94*# | 38.96±5.68*# | 44.22±7.09*# | 42.84±6.32* | ||
PDPN组 | 5.89±0.74**##△ | 47.82±4.50**#△ | 36.63±4.73*# | 38.22±6.24*# | 41.28±6.88*# | 35.74±7.63*#△ | ||
统计值 | 13.226 | 16.808 | 9.025 | 10.307 | 7.523 | 11.897 | ||
P值 | 0.000 | 0.000 | 0.004 | 0.001 | 0.015 | 0.001 |
组别 | 例数 | 年龄/岁 | 性别 | BMI/ (kg/m2) | 糖尿病 病程/年 | 吸烟史/ 例 | 家族史/ 例 | |
---|---|---|---|---|---|---|---|---|
男/例 | 女/例 | |||||||
正常对照组 | 42 | 58.19±8.63 | 26 | 16 | 22.74±1.04 | 16 | 4 | |
单纯T2DM组 | 63 | 59.51±8.88 | 41 | 22 | 25.97±1.09* | 5.79±1.85 | 26 | 9 |
NPDPN组 | 77 | 58.91±9.01 | 55 | 22 | 26.76±1.19* | 10.11±2.17## | 33 | 10 |
PDPN组 | 58 | 58.12±8.96 | 39 | 19 | 26.03±1.27* | 10.29±2.09## | 24 | 8 |
统计值 | 1.023 | 1.284 | 7.692 | 9.024 | 0.255 | 0.575 | ||
P值 | 0.872 | 0.733 | 0.016 | 0.006 | 0.968 | 0.902 | ||
组别 | FBG/ (mmol/L) | 2 h PG/(mmol/L) | TG/ (mmol/L) | TC/ (mmol/L) | LDL-C/(mmol/L) | HDL-C/(mmol/L) | HbA1c/% | |
正常对照组 | 5.23±0.62 | 6.48±0.63 | 1.53±0.28 | 4.57±0.68 | 2.19±0.65 | 1.34±0.27 | 5.27±0.57 | |
单纯T2DM组 | 7.69±0.86* | 8.27±0.84* | 1.88±0.31 | 4.62±0.73 | 2.64±0.71 | 0.96±0.28* | 7.40±0.62* | |
NPDPN组 | 8.22±0.91** | 9.18±0.81* | 1.92±0.37* | 4.82±0.79 | 2.69±0.73 | 0.86±0.31* | 7.61±0.71* | |
PDPN组 | 9.45±0.87**#△ | 9.74±1.96** | 2.62±0.52**# | 4.81±1.04 | 3.03±0.97 | 0.77±0.39**# | 8.73±0.74**#△ | |
统计值 | 11.352 | 9.291 | 10.807 | 0.996 | 7.656 | 11.882 | 12.754 | |
P值 | 0.001 | 0.006 | <0.001 | 0.742 | 0.054 | 0.005 | <0.001 | |
组别 | BDNF/(ng/mL) | HMGB1/(ng/mL) | MMCV/(m/s) | PMCV/(m/s) | MSCV/(m/s) | PSCV/(m/s) | ||
正常对照组 | 10.44±1.19 | 28.47±2.87 | 49.65±5.01 | 51.30±5.63 | 55.94±6.95 | 54.61±4.86 | ||
单纯T2DM组 | 8.09±0.86* | 35.41±3.49* | 43.57±6.55* | 43.87±6.11* | 47.58±6.24* | 46.52±5.81* | ||
NPDPN组 | 7.13±0.81** | 41.28±3.87**# | 38.47±5.94*# | 38.96±5.68*# | 44.22±7.09*# | 42.84±6.32* | ||
PDPN组 | 5.89±0.74**##△ | 47.82±4.50**#△ | 36.63±4.73*# | 38.22±6.24*# | 41.28±6.88*# | 35.74±7.63*#△ | ||
统计值 | 13.226 | 16.808 | 9.025 | 10.307 | 7.523 | 11.897 | ||
P值 | 0.000 | 0.000 | 0.004 | 0.001 | 0.015 | 0.001 |
组别 | 例 | LAGE/(mmol/L) | MBG/(mmol/L) | SDBG/(mmol/L) | FBG-CV/% |
---|---|---|---|---|---|
正常对照组 | 42 | 3.29±1.04 | 2.97±0.51 | 0.91±0.27 | 17.26±3.29 |
单纯T2DM组 | 63 | 5.71±1.40* | 4.21±0.49* | 1.46±0.34* | 25.41±4.22* |
NPDPN组 | 77 | 6.87±1.38**# | 4.68±0.51* | 1.76±0.29**# | 29.41±3.96* |
PDPN组 | 58 | 8.46±1.82**##△ | 7.69±0.62**##△ | 2.81±0.31**##△ | 41.23±4.13**##△ |
F值 | 11.682 | 9.928 | 10.323 | 15.026 | |
P值 | 0.006 | 0.017 | 0.001 | 0.000 |
组别 | 例 | LAGE/(mmol/L) | MBG/(mmol/L) | SDBG/(mmol/L) | FBG-CV/% |
---|---|---|---|---|---|
正常对照组 | 42 | 3.29±1.04 | 2.97±0.51 | 0.91±0.27 | 17.26±3.29 |
单纯T2DM组 | 63 | 5.71±1.40* | 4.21±0.49* | 1.46±0.34* | 25.41±4.22* |
NPDPN组 | 77 | 6.87±1.38**# | 4.68±0.51* | 1.76±0.29**# | 29.41±3.96* |
PDPN组 | 58 | 8.46±1.82**##△ | 7.69±0.62**##△ | 2.81±0.31**##△ | 41.23±4.13**##△ |
F值 | 11.682 | 9.928 | 10.323 | 15.026 | |
P值 | 0.006 | 0.017 | 0.001 | 0.000 |
项目 | AUC(95%可信区间) | P值 | 敏感性/% | 特异性/% | 阳性预测值/% | 阴性预测值/% | 准确性/% |
---|---|---|---|---|---|---|---|
LAGE | 0.748(0.622~0.874) | 0.003 | 74.14 | 84.06 | 59.72 | 91.07 | 81.56 |
MBG | 0.727(0.576~0.877) | 0.009 | 70.69 | 82.42 | 56.16 | 89.82 | 80.32 |
SDBG | 0.785(0.675~0.895) | 0.001 | 77.59 | 85.16 | 62.50 | 92.26 | 83.24 |
FBG-CV | 0.837(0.712~0.948) | 0.000 | 84.48 | 89.56 | 72.06 | 94.77 | 85.84 |
项目 | AUC(95%可信区间) | P值 | 敏感性/% | 特异性/% | 阳性预测值/% | 阴性预测值/% | 准确性/% |
---|---|---|---|---|---|---|---|
LAGE | 0.748(0.622~0.874) | 0.003 | 74.14 | 84.06 | 59.72 | 91.07 | 81.56 |
MBG | 0.727(0.576~0.877) | 0.009 | 70.69 | 82.42 | 56.16 | 89.82 | 80.32 |
SDBG | 0.785(0.675~0.895) | 0.001 | 77.59 | 85.16 | 62.50 | 92.26 | 83.24 |
FBG-CV | 0.837(0.712~0.948) | 0.000 | 84.48 | 89.56 | 72.06 | 94.77 | 85.84 |
项目 | BDNF | HMGB1 | MMCV | PMCV | MSCV | PSCV |
---|---|---|---|---|---|---|
LAGE | ||||||
r值 | -0.417 | 0.446 | -0.204 | -0.517 | -0.146 | -0.173 |
P值 | 0.018 | 0.009 | 0.078 | 0.000 | 0.094 | 0.080 |
MBG | ||||||
r值 | -0.422 | 0.189 | -0.165 | -0.482 | -0.212 | -0.123 |
P值 | 0.018 | 0.089 | 0.089 | 0.004 | 0.078 | 0.097 |
SDBG | ||||||
r值 | -0.439 | 0.408 | -0.421 | -0.506 | -0.185 | -0.458 |
P值 | 0.011 | 0.019 | 0.015 | 0.000 | 0.076 | 0.010 |
FBG-CV | ||||||
r值 | -0.501 | 0.492 | -0.388 | -0.514 | -0.347 | -0.479 |
P值 | 0.000 | 0.000 | 0.029 | 0.000 | 0.034 | 0.009 |
项目 | BDNF | HMGB1 | MMCV | PMCV | MSCV | PSCV |
---|---|---|---|---|---|---|
LAGE | ||||||
r值 | -0.417 | 0.446 | -0.204 | -0.517 | -0.146 | -0.173 |
P值 | 0.018 | 0.009 | 0.078 | 0.000 | 0.094 | 0.080 |
MBG | ||||||
r值 | -0.422 | 0.189 | -0.165 | -0.482 | -0.212 | -0.123 |
P值 | 0.018 | 0.089 | 0.089 | 0.004 | 0.078 | 0.097 |
SDBG | ||||||
r值 | -0.439 | 0.408 | -0.421 | -0.506 | -0.185 | -0.458 |
P值 | 0.011 | 0.019 | 0.015 | 0.000 | 0.076 | 0.010 |
FBG-CV | ||||||
r值 | -0.501 | 0.492 | -0.388 | -0.514 | -0.347 | -0.479 |
P值 | 0.000 | 0.000 | 0.029 | 0.000 | 0.034 | 0.009 |
项目 | β值 | 标准误 | Wald值 | OR值(95%可信区间) | P值 |
---|---|---|---|---|---|
LAGE | 0.643 | 0.577 | 8.022 | 1.988(1.024~7.661) | 0.011 |
MBG | 0.597 | 0.463 | 6.554 | 1.804(1.091~5.534) | 0.029 |
SDBG | 0.762 | 0.683 | 10.835 | 2.704(1.557~9.836) | 0.001 |
FBG-CV | 0.682 | 0.594 | 11.432 | 2.681(1.633~9.827) | 0.000 |
项目 | β值 | 标准误 | Wald值 | OR值(95%可信区间) | P值 |
---|---|---|---|---|---|
LAGE | 0.643 | 0.577 | 8.022 | 1.988(1.024~7.661) | 0.011 |
MBG | 0.597 | 0.463 | 6.554 | 1.804(1.091~5.534) | 0.029 |
SDBG | 0.762 | 0.683 | 10.835 | 2.704(1.557~9.836) | 0.001 |
FBG-CV | 0.682 | 0.594 | 11.432 | 2.681(1.633~9.827) | 0.000 |
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