Research status and application prospects of biomarkers for membranous nephropathy

doi:10.3969/j.issn.1673-8640.2023.12.001

Abstract

Abstract:

Membranous nephropathy（MN） is the most common pathological type of adult nephrotic syndrome and a significant contributor to adult end-stage renal disease. The course of MN varies，with 1/3 patients experiencing spontaneous remission or stable disease，while 1/3 patients continue to progress. Without timely diagnosis and standardized treatment，MN can lead to end-stage renal disease. Therefore，early determination of patients with poor prognosis，timely standardized treatment and regular follow-up are crucial. Renal biopsy is the gold standard for diagnosing MN. Recently，the clinical application of anti-M-type phospholipase A2 receptor（PLA2R） antibody determination has improved the diagnosis and treatment of MN. According to the latest MN diagnosis and treatment guidelines，it is now clear that renal biopsy is not necessary to confirm the diagnosis of MN after ruling out secondary MN. With research progress，several new potential markers for MN，including thrombospondin type1 domain-containing 7A（THSD7A），have been discovered. These markers are valuable for assisting in the diagnosis of anti-PLA2R antibody-negative MN. Therefore，it is important to conduct further clinical research on these new MN biomarkers and utilize a comprehensive approach to their application in order to enhance the accuracy of MN diagnosis and treatment.

Key words: M-type phospholipase A2 receptor, Autoantibody, Membranous nephropathy

CLC Number:

R446.1

FAN Lieying. Research status and application prospects of biomarkers for membranous nephropathy[J]. Laboratory Medicine, 2023, 38(12): 1111-1114.

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