Clinical significance on the determinations of serum autoantibodies and thyroid hormone in patients with vitiligo

doi:10.3969/j.issn.1673-8640.2015.09.003

Abstract

Abstract: Objective

To investigate the levels and clinical significance of serum autoantibodies and thyroid hormone in patients with vitiligo.

Methods

The anti-nuclear antibody (ANA), anti-nuclear antibody spectrum(ANAS), free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroglobulin antibody (TG-Ab) and thyroid peroxidase antibody (TPO-Ab) were determined in 123 patients with vitiligo and 60 healthy controls by indirect immunofluorescence, immunoblotting and chemiluminescence. The determination items were statistically compared between vitiligo group and control group.

Results

The positive rates of ANA, TG-Ab and TPO-Ab in vitiligo group were higher than those in control group(P<0.01), while ANAS was not statistically significant between the 2 groups (P>0.05). FT3 and FT4 were not statistically significant in the 2 groups(P>0.05). TSH in vitiligo group was higher than that in control group (P<0.05).

Conclusions

The relationship is close between vitiligo and thyroid autoimmune diseases. ANA, TG-Ab, TPO-Ab and TSH determinations can be usually used in vitiligo patients with autoimmune diseases.

Key words: Autoantibody, Thyroid hormone, Autoimmune, Vitiligo

CLC Number:

R446.62

WU Junqi, YAO Aiping, WANG Meiyan, JIANG Yixiu, LU Xiaodong. Clinical significance on the determinations of serum autoantibodies and thyroid hormone in patients with vitiligo[J]. Laboratory Medicine, 2015, 30(9): 877-880.

Figures/Tables 2

References 16

[1]	MALHOTRA N, DYTOC M.The pathogenesis of vitiligo[J]. J Cutan Med Surg, 2013,17(3):153-172.
[2]	SRAVANI PV, BABU NK, COPAL KV, et al.Determinination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin[J]. Indian J Dermatol Venereol Leprol, 2009,75(3):268-271.
[3]	SHENEEF A, EZZ-EI DR,MAHMOUD TM.Flow cytometric analysis of peripheral blood lymphocytes in patients with vitiligo[J]. Egypt J lmmunol,2012,19(1):31-38.
[4]	INGORDO V,CAZZANIGA S,RAONE B,et al.Circulating autoantibodies and autoimmune comorbidities in vitiligo patients: a multicenter Italian study[J]. Dermatology, 2014,228(3):240-249.
[5]	LILI Y, YI W, JI Y, et al.Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo[J]. PLoS One, 2012,7(5):e37513.
[6]	中国中西医结合学会皮肤性病专业委员会色素病学组. 白癜风临床分型及疗效标准(2003年修订稿)[J]. 中华皮肤科杂志,2004,37(7):440.
[7]	SAWICKI J, SIDDHA S,ROSEN C.Vitiligo and associated autoimmune disease: retrospective review of 300 patients[J]. J Cutan Med Surg, 2012,16(4):261-266.
[8]	SHETH VM, GUO Y, QURESHI AA.Comorbidities associated with vitiligo: a ten-year retrospective study[J]. Dermatology,2013,227(4):311-315.
[9]	KASUMAGIC-HALILOVIC E, OVCINA-KURTOVIC N,JUKIC T, et al.Vitiligo and autoimmunity[J]. Med Arch, 2013,67(2):91-93.
[10]	INGORDO V, GENTILE C,IANNAZZONE SS,et al.Vitiligo and autoimmunity:an epidemiogical study in a representative sample of young Italian males[J].J Eur Acad Dermatol Venereol,2011,25(1):105-109.
[11]	杨一芬,卿之驹,肖嵘,等. 白癜风患者血清甲状腺球蛋白抗体和甲状腺过氧化物酶抗体的检测[J]. 中华皮肤科杂志,2009,42(5):333-335.
[12]	YANG Y, LIN X,FU W,et al.An approach to the correlation between vitiligo and autoimmune thyroiditis in Chinese children[J]. Clin Exp Dermatol,2010,35(7):706-710.
[13]	贾名妍,苗青,于伟,等. 白癜风患者血清甲状腺自身抗体水平研究[J].中国美容医学杂志,2013,22(14):1503-1506.
[14]	REZAEI N,GAVALAS NG,WEETMAN AP, et al.Autoimmunity as an aetiogical factor in vitiligo[J]. J Eur Acad Dermatol Venereol,2007,21(7):865-876.
[15]	SEDIGHE M,GHOLAMHOSSEIN G.Thyroid dysfunction and thyroid antibodies in Iranian patients with vitiligo[J]. Indian J Dermatol, 2008,53(1):9-11.
[16]	IACOVELLI P, SINAGRA JL, VIDOLIN AP,et al.Relevance of thyroiditis and of other autoimmune disesses in children with vitiligo[J]. Dermatology, 2005,210(1):26-30.

组别	例数	ANA阳性	ANAS阳性	TG-Ab阳性	TPO-Ab阳性
白癜风组	123	28(22.76)^**	8(6.50)	20(16.26)^*	21(17.15)^*
正常对照组	60	2(3.33)	1(1.66)	3(5.00)	2(3.33)

组别	例数	ANA阳性	ANAS阳性	TG-Ab阳性	TPO-Ab阳性
白癜风组	123	28(22.76)^**	8(6.50)	20(16.26)^*	21(17.15)^*
正常对照组	60	2(3.33)	1(1.66)	3(5.00)	2(3.33)

组别	例数	FT3(pmol/L)	FT4 (pmol/L)	TSH (mIU/L)
白癜风组	123	4.52±1.52	15.23±3.66	2.77±1.02^*
正常对照组	60	4.63±1.66	14.36±3.92	2.13±0.96

组别	例数	FT3(pmol/L)	FT4 (pmol/L)	TSH (mIU/L)
白癜风组	123	4.52±1.52	15.23±3.66	2.77±1.02^*
正常对照组	60	4.63±1.66	14.36±3.92	2.13±0.96