Research progress in laboratory diagnosis of IgG4-related diseases

doi:10.3969/j.issn.1673-8640.2018.011.016

Abstract

Abstract:

IgG4-related disease （IgG4-RD） is a newly recognized autoimmune disease characterized by fibrotic inflammation. The pathological features are IgG4⁺ plasma cell infiltration,tabular fibrosis and occlusive phlebitis,and IgG4-RD was accompanied with elevated serum IgG4 levels. Most human organs can be affected,which can result in anthorisma due to chronic inflammation and fibrosis. Descendiblity,immue,microbial infection and molecular simulation are involved in its pathogenesis. At present,pathological diagnosis is still the gold standard for the diagnosis of IgG4-RD,but laboratory serological determination and immune cell analysis have the advantages of quantitation,convenience and accuracy,and they are irreplaceable. This review focuses on the naming,pathogenesis and laboratory diagnosis of IgG4-RD.

Key words: IgG4-related disease, Autoimmune disease, Fibrosis, IgG4⁺ plasma cell

CLC Number:

R446.1

SHU Jie, SHENG Huiming. Research progress in laboratory diagnosis of IgG4-related diseases[J]. Laboratory Medicine, 2018, 33(11): 1043-1048.

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