Roles of HA,Ⅳ-C,APRI and Fib-4 in the diagnosis of hepatitis B-related liver fibrosis

doi:10.3969/j.issn.1673-8640.2019.06.013

Abstract

Abstract:

Objective To evaluate the diagnosis efficiency of hyaluronic acid（HA） and Ⅳ-collagen（Ⅳ-C）in patients with liver fibrosis after hepatitis B. Aspartate aminotransferase（AST）/platelet（PLT） ratio（APRI） and fibrosis 4 score（Fib-4）for liver fibrosis after hepatitis B. Methods A total of 320 patients with hepatitis B were enrolled. Their general data,like age and sex,were recorded. The patients were classified according to the Metavir scoring system. The HA and Ⅳ-C levels were detected by chemiluminescence,and APRI and Fib-4 were calculated. Their roles have been evaluated according to receiver operating characteristic（ROC）curve analysis. Results HA,Ⅳ-C,APRI and Fib-4 were positively correlated with the stage of liver fibrosis with statistical significance（P<0.05）,and the areas under curves（AUC） of HA,Ⅳ-C,APRI and Fib-4 were 0.646,0.695,0.743 and 0.701,respectively. Conclusions HA,Ⅳ-C,APRI and Fib-4 have correlations with hepatitis B-related liver fibrosis. They are potential in the non-invasive diagnosis of hepatitis B-related liver fibrosis.

Key words: Hyaluronic acid, Ⅳ-collagen, Aspartate aminotransferase/platelet ratio, Fibrosis 4 score, Chronic hepatitis B, Liver fibrosis

CLC Number:

R446.1

YU Xiaochun, HU Xujiao, ZHANG Jiaqing, GUO Leilei. Roles of HA,Ⅳ-C,APRI and Fib-4 in the diagnosis of hepatitis B-related liver fibrosis[J]. Laboratory Medicine, 2019, 34(6): 539-542.

Figures/Tables 3

References 13

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肝纤维化分期	性别		年龄（岁）	HA （ng/mL）	Ⅳ-C （ng/mL）	APRI（ng/mL）	Fib-4（ng/mL）
肝纤维化分期	男（例）	女（例）	年龄（岁）	HA （ng/mL）	Ⅳ-C （ng/mL）	APRI（ng/mL）	Fib-4（ng/mL）
F0	21	10	45.10±11.60	71.77±38.41	68.41±31.58	0.25（0.16~0.34）	0.96（0.54~1.38）
F1	59	20	42.50±14.10	83.71±35.26	79.56±40.15	0.44（0.33~0.55）	1.14（0.85~1.41）
F2	65	12	41.60±9.80	91.44±40.51	90.46±50.47	1.05（0.41~1.63）	1.87（1.13~2.61）
F3	26	19	46.70±10.40	98.47±43.16	105.47±52.55	1.41（0.58~2.24）	2.00（1.41~2.69）
F4	9	4	40.30±7.40	118.74±49.24	119.89±42.62	1.68（0.76~2.60）	3.18（2.12~4.70）
P值	0.945		0.64	<0.05	<0.05	<0.05	<0.05

肝纤维化分期	性别		年龄（岁）	HA （ng/mL）	Ⅳ-C （ng/mL）	APRI（ng/mL）	Fib-4（ng/mL）
肝纤维化分期	男（例）	女（例）	年龄（岁）	HA （ng/mL）	Ⅳ-C （ng/mL）	APRI（ng/mL）	Fib-4（ng/mL）
F0	21	10	45.10±11.60	71.77±38.41	68.41±31.58	0.25（0.16~0.34）	0.96（0.54~1.38）
F1	59	20	42.50±14.10	83.71±35.26	79.56±40.15	0.44（0.33~0.55）	1.14（0.85~1.41）
F2	65	12	41.60±9.80	91.44±40.51	90.46±50.47	1.05（0.41~1.63）	1.87（1.13~2.61）
F3	26	19	46.70±10.40	98.47±43.16	105.47±52.55	1.41（0.58~2.24）	2.00（1.41~2.69）
F4	9	4	40.30±7.40	118.74±49.24	119.89±42.62	1.68（0.76~2.60）	3.18（2.12~4.70）
P值	0.945		0.64	<0.05	<0.05	<0.05	<0.05

血清学指标	r值	P值
HA	0.33	<0.01
Ⅳ-C	0.48	<0.01
APRI	0.51	<0.01
Fib-4	0.65	<0.01

血清学指标	r值	P值
HA	0.33	<0.01
Ⅳ-C	0.48	<0.01
APRI	0.51	<0.01
Fib-4	0.65	<0.01

血清学指标	临界值	敏感性（%）	特异性（%）
HA	89.2	60.0	71.0
Ⅳ-C	80.7	70.0	85.0
APRI	1.3	75.0	90.0
Fib-4	1.4	71.7	85.0
4项联合	94.1	95.8	91.6