Clinical values of IL-1β,IL-6 and TNF-α in different clinical courses of chronic HBV infection

doi:10.3969/j.issn.1673-8640.2021.08.002

Abstract

Abstract:

Objective To investigate the clinical values of interleukin（IL）-1β,IL-6 and tumor necrosis factor-alpha（TNF-α） in patients with different clinical courses of chronic hepatitis B virus（HBV） infection. Methods Totally,240 patients with chronic HBV infection were enrolled and classified into 60 patients with asymptomatic carriers（ASC）（ASC group）,60 patients with chronic hepatitis B（CHB）（CHB group）,60 patients with liver cirrhosis（LC）（LC group） and 60 patients with hepatocellular carcinoma（HCC）（HCC group）. Sixty healthy subjects were enrolled as healthy control group. Serum IL-1β,IL-6,TNF-α,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total bilirubin（TB）,albumin（Alb） and HBV DNA load were determined. Results The levels of IL-1β,IL-6 and TNF-α in ASC group,CHB group,LC group and HCC group were higher than those in healthy control group（P<0.01）. The levels of IL-1β and IL-6 in HCC group were lower than those in ASC group,CHB group and LC group（P<0.01）,and the TNF-α levels in ASC group were lower than those in LC group（P<0.01）. There was no statistical significance for the other indicators among the groups（P>0.05）. There was no correlation between IL-1β,IL-6,TNF-α and HBV DNA load,ALT,AST,TB and Alb in ASC group and CHB group（P>0.05）. Except for the negative correlation between IL-6 and ALT in LC group（r=-0.314,P<0.05）,there was no correlation among the other indicators（P>0.05）. Except for the negative correlation between TNF-α and HBV DNA load in HCC group（r=-0.348,P<0.05）,there was no correlation among the other indicators（P>0.05）. Conclusions Serum IL-1β,IL-6 and TNF-α levels may be used to assess the severity of patients with chronic HBV infection.

Key words: Interleukin-1 beta, Interleukin-6, Tumor necrosis factor-alpha, Hepatitis B virus, Chronic hepatitis B

CLC Number:

R446.1

LI Caidong, ZHANG Xuqiang, LEI Zhiping, CHEN Qiaoli, CHEN Lu, TIAN Pengfei, DUAN Zhengjun. Clinical values of IL-1β,IL-6 and TNF-α in different clinical courses of chronic HBV infection[J]. Laboratory Medicine, 2021, 36(8): 790-794.

Figures/Tables 7

References 19

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组别	例数	IL-1β/（pg/mL）	IL-6/（ng/L）	TNF-α/（ng/L）
ASC组	60	804.80±154.24^*	95.12±12.37^*	64.38±24.89^*▲
CHB组	60	710.43±152.89^*	80.93±10.87^*	82.44±26.54^*
LC组	60	733.26±106.85^*	76.26±10.57^*	108.50±33.64^*
HCC组	60	391.50±38.57^*#	52.14±3.06^*#△▲	85.69±36.26^*
正常对照组	60	118.55±74.05	25.79±5.41	33.57±16.58

组别	例数	IL-1β/（pg/mL）	IL-6/（ng/L）	TNF-α/（ng/L）
ASC组	60	804.80±154.24^*	95.12±12.37^*	64.38±24.89^*▲
CHB组	60	710.43±152.89^*	80.93±10.87^*	82.44±26.54^*
LC组	60	733.26±106.85^*	76.26±10.57^*	108.50±33.64^*
HCC组	60	391.50±38.57^*#	52.14±3.06^*#△▲	85.69±36.26^*
正常对照组	60	118.55±74.05	25.79±5.41	33.57±16.58

项目	ALT		AST		TB		Alb		HBV DNA载量
项目	r值	P值	r值	P值	r值	P值	r值	P值	r值	P值
IL-1β	0.016	0.906	0.193	0.141	-0.113	0.388	0.062	0.39	-0.153	0.281
IL-6	0.103	0.435	0.003	0.984	-0.109	0.408	-0.180	0.170	-0.056	0.736
TNF-α	-0.035	0.789	0.178	0.173	-0.185	0.158	0.051	0.701	0.117	0.357

项目	ALT		AST		TB		Alb		HBV DNA载量
项目	r值	P值	r值	P值	r值	P值	r值	P值	r值	P值
IL-1β	0.016	0.906	0.193	0.141	-0.113	0.388	0.062	0.39	-0.153	0.281
IL-6	0.103	0.435	0.003	0.984	-0.109	0.408	-0.180	0.170	-0.056	0.736
TNF-α	-0.035	0.789	0.178	0.173	-0.185	0.158	0.051	0.701	0.117	0.357

项目	ALT		AST		TB		Alb		HBV DNA载量
项目	r值	P值	r值	P值	r值	P值	r值	P值	r值	P值
IL-1β	0.073	0.581	0.101	0.441	-0.047	0.723	0.102	0.440	0.045	0.733
IL-6	0.062	0.639	0.009	0.946	-0.117	0.372	0.010	0.939	0.124	0.344
TNF-α	-0.111	0.398	-0.169	0.198	-0.028	0.835	-0.021	0.874	-0.164	0.212