Abstract:

Objective To investigate the diagnostic value of serum total immunoglobulin E（IgE） antibody,allergen specific immunoglobulin E（sIgE） antibody,interleukin（IL）-6 and C-reactive protein（CRP） levels in patients with acute urticaria. Methodsb From June 2018 to December 2019,75 patients with urticarial treated in our hospital were selected as study group,and 75 healthy persons were selected as control group. The diagnostic value of total IgE antibody,sIgE antibody,CRP and IL-6 in acute urticarial were compared between the two groups. Results The positive rate of serum total IgE antibody in the study group was significantly higher than that in the control group（P<0.05）. The positive rate of sIgE antibody was significantly higher than that of the total IgE antibody in the study group（P<0.05）. The serum CRP and IL-6 levels of the study group were significantly higher than those of the control group（P<0.05）. The level of serum IL-6 in the study group was correlated with the level of total IgE antibody（r=0.595,P<0.05）. Conclusion The combined detection and comprehensive evaluation of serum total IgE,sIgE,CRP and IL-6 have clinical value for early screening and diagnosis of acute urticaria.

Key words: Acute urticaria, Allergen, Total IgE antibody, sIgE antibody, C-reactive protein, Interleukin-6