Correlation of gestational diabetes mellitus with plasma TMAO

doi:10.3969/j.issn.1673-8640.2021.08.003

Abstract

Abstract:

Objective To investigate the correlation between plasma trimethylamine oxide（TMAO）and gestational diabetes mellitus（GDM）. Methods Totally,272 singleton pregnant women were enrolled and determined for oral glucose tolerance test（OGTT） from 24 to 28 gestational weeks. There were 178 cases of GDM and 94 cases of healthy pregnant women（control group）. The general data of all pregnant women were recorded. Serum triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein（apo）A1,apo B100,alanine aminotransferase（ALT） and fasting blood glucose （FBG） levels were determined during early pregnancy（gestational week≤13）,and TMAO levels in the second and third trimesters of pregnancy were determined as well. Multiple Logistic regression analysis was used to assess the risk factors of GDM. Results The levels of TG and FBG in the early pregnancy in GDM group were higher than those in control group（P<0.05）,and the levels of ALT,TC,HDL-C,LDL-C,apo A1 and apo B100 in GDM group had no statistical significance from those in control group（P>0.05）. The level of TMAO in GDM group was higher than that in control group（P<0.05）. There was no statistical significance in TMAO level between the second and third trimesters of pregnancy in GDM group（P>0.05）. Multiple Logistic regression analysis showed that the increase of FBG [odds ratio（OR）=3.883,95% confidence interval（CI） 1.805-8.353],TG（OR=2.146,95%CI 1.245-3.702） and TMAO（OR=1.514,95%CI 1.079-2.125） were independent risk factors for GDM. Conclusions Plasma TMAO levels in the second trimester are positively associated with the risk of GDM.

Key words: Trimethylamine oxide, Gut bacterium metabolite, Gestational diabetes mellitus, Risk factor

CLC Number:

R446.1

LE Jiangman, LI Tianyuan, TAN Meiyu, WANG Yajie, ZHOU Lida, SHU Jie, WU Jiaoxiang, SUN Hanxiao, XUAN Binbin, CAI Xushan, SHENG Huiming. Correlation of gestational diabetes mellitus with plasma TMAO[J]. Laboratory Medicine, 2021, 36(8): 795-799.

Figures/Tables 3

References 22

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组别	例数	年龄/岁	孕周/周	孕前BMI/（kg/m²）	孕前收缩压/kPa	孕前舒张压/kPa
GDM组	178	30（28~33）	22.4（21.8~23.0）	22.68（20.70~25.62）	14.86±1.60	9.18（8.25~10.37）
正常妊娠组	94	29（27~31）	22.6（22.0~23.0）	22.48（20.25~24.86）	14.53±1.45	8.78（7.98~9.61）
统计值		2.848	0.743	1.379	1.710	2.381
P值		0.004	0.458	0.168	0.088	0.017
组别		孕次≥2次/ [例（%）]	父亲糖尿病史/ [例（%）]	母亲糖尿病史/ [例（%）]	父亲高血压病史/[例（%）]	母亲高血压病史/ [例（%）]
GDM组		123（69.1）	3（1.7）	3（1.7）	27（15.2）	36（20.2）
正常妊娠组		65（69.1）	1（1.1）	1（1.1）	16（17.0）	14（14.9）
统计值		0.000	0.000	0.000	0.159	1.165
P值		0.994	1.000	1.000	0.690	0.280

组别	例数	年龄/岁	孕周/周	孕前BMI/（kg/m²）	孕前收缩压/kPa	孕前舒张压/kPa
GDM组	178	30（28~33）	22.4（21.8~23.0）	22.68（20.70~25.62）	14.86±1.60	9.18（8.25~10.37）
正常妊娠组	94	29（27~31）	22.6（22.0~23.0）	22.48（20.25~24.86）	14.53±1.45	8.78（7.98~9.61）
统计值		2.848	0.743	1.379	1.710	2.381
P值		0.004	0.458	0.168	0.088	0.017
组别		孕次≥2次/ [例（%）]	父亲糖尿病史/ [例（%）]	母亲糖尿病史/ [例（%）]	父亲高血压病史/[例（%）]	母亲高血压病史/ [例（%）]
GDM组		123（69.1）	3（1.7）	3（1.7）	27（15.2）	36（20.2）
正常妊娠组		65（69.1）	1（1.1）	1（1.1）	16（17.0）	14（14.9）
统计值		0.000	0.000	0.000	0.159	1.165
P值		0.994	1.000	1.000	0.690	0.280

组别	例数	ALT/（U/L）		TG/（mmol/L）		TC/（mmol/L）	HDL-C/（mmol/L）
GDM组	178	15（10~23）		1.56（1.22~2.10）		4.96±0.83	1.64±0.32
正常妊娠组	94	13（9~21）		1.43（1.08~1.68）		4.88±0.83	1.72±0.32
统计值		1.613		2.995		0.700	1.804
P值		0.107		0.003		0.484	0.073
组别	LDL-C/（mmol/L）		apo A1/（g/L）		apoB100/（g/L）		FBG/（mmol/L）
GDM组	2.90±0.76		1.73±0.22		0.92±0.19		4.55（4.25~4.91）
正常妊娠组	2.82±0.70		1.74±0.20		0.88±0.19		4.34（4.14~4.59）
统计值	0.866		0.113		1.837		3.774
P值	0.387		0.911		0.068		0.000

组别	例数	ALT/（U/L）		TG/（mmol/L）		TC/（mmol/L）	HDL-C/（mmol/L）
GDM组	178	15（10~23）		1.56（1.22~2.10）		4.96±0.83	1.64±0.32
正常妊娠组	94	13（9~21）		1.43（1.08~1.68）		4.88±0.83	1.72±0.32
统计值		1.613		2.995		0.700	1.804
P值		0.107		0.003		0.484	0.073
组别	LDL-C/（mmol/L）		apo A1/（g/L）		apoB100/（g/L）		FBG/（mmol/L）
GDM组	2.90±0.76		1.73±0.22		0.92±0.19		4.55（4.25~4.91）
正常妊娠组	2.82±0.70		1.74±0.20		0.88±0.19		4.34（4.14~4.59）
统计值	0.866		0.113		1.837		3.774
P值	0.387		0.911		0.068		0.000

因素	B值	标准误	Wald值	P值	OR值（95%CI）
孕中期TMAO	0.415	0.173	5.759	0.016	1.514（1.079~2.125）
孕早期TG	0.764	0.278	7.546	0.006	2.146（1.245~3.702）
孕早期FPG	1.357	0.391	12.05	0.001	3.883（1.805~8.353）