Abstract:

Objective To evaluate the changes of carbohydrate antigen 125（CA125） in pregnancy,and to investigate the relationship of CA125 with other biochemical indicators. Methods A total of 167 pregnant and 46 non-pregnant women were enrolled. Of the 167 pregnant women,57 cases were in the first trimester of pregnancy（8-12 weeks）,55 cases were in the second trimester of pregnancy（15-19 weeks）,and 55 cases were in the third trimester of pregnancy（33-36 weeks）. Serum levels of CA125,creatinine（Cr）,alkaline phosphatase（ALP）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,blood urea nitrogen（BUN）,blood glucose（Glu）,triglyceride（TG） and total cholesterol（TC） were determined. The correlations of biochemical indicators and CA125 were evaluated by Pearson correlation analysis. Results The levels of serum CA125,ALP,TG and TC in pregnant women were higher than those in non-pregnant women（P<0.05）,and Cr,BUN and Glu were lower（P<0.001）. Serum ALT and AST had no statistical significance between pregnant and non-pregnant women（P>0.05）. The CA125 level was higher in the first trimester than those in the third and second trimesters of pregnancy（P<0.05）,and that in the third trimester was higher than that in the second trimester of pregnancy（P<0.05）. The levels of serum ALP,TG and TC in the third trimester were higher,and ALT and Glu were lower than those in the first and second trimesters of pregnancy（P<0.05）. There was no statistical significance between the first and second trimesters of pregnancy（P>0.05）. There was no statistical significance for Cr,BUN and AST among all pregnant groups（P>0.05）. BUN（r=0.221,P<0.05） and Glu（r=0.165,P<0.05）were positively correlated with CA125 in pregnancy,while Cr,ALP,ALT,AST,TC and TG were not correlated with CA125 （r=-0.005,-0.059,0.028,0.028,-0.140 and -0.071,respectively,P>0.05）. Conclusions Serum CA125 levels are increased during pregnancy,especially in early pregnancy,and the levels of CA125 during pregnancy are associated with BUN and Glu.

Key words: Carbohydrate antigen 125, Blood glucose, Blood urea nitrogen, Pregnancy