Abstract:

Objective To investigate the roles of carcinoembryonic antigen（CEA）,carbohydrate antigen （CA） 125,neuron specific enolase（NSE） and cytokeratin-19-fragment（CYFRA21-1） in the auxiliary diagnosis and chemotherapy efficacy evaluation of lung cancer. Methods A total of 86 patients with lung cancer（lung cancer group） were enrolled,which were classified into 36 cases of squamous carcinoma,29 cases of adenocarcinoma and 21 cases of small cell carcinoma,and 30 healthy subjects were enrolled as healthy control group. The levels of CEA,CA125,NSE and CYFRA21-1 were determined. The auxiliary diagnosis efficacy of the 4 serum tumor markers for lung cancer was evaluated,and the consistency with computed tomography（CT） efficacy evaluation was analyzed. Results Serum CEA,CA125,NSE and CYFRA21-1 in lung cancer group were higher than those in healthy control group（P<0.05）. The levels of CEA and CA125 in adenocarcinoma group were higher than those in squamous carcinoma and small cell carcinoma groups（P<0.05）,the levels of CYFRA21-1 in squamous carcinoma group was higher than those in adenocarcinoma and small cell carcinoma groups（P<0.05）,and the level of NSE in small cell carcinoma was higher than those in adenocarcinoma and squamous carcinoma groups（P<0.05）. The sensitivity,specificity and area under receiver operating characteristic（ROC） curve（AUC） of the combined determination of the 4 serum tumor markers were higher than those of their single determinations. CEA and CA125 had good consistencies with CT（Kappa values were 0.508 and 0.470,P<0.001）. Conclusions CEA,CA125,NSE and CYFRA21-1 have auxiliary diagnostic values for lung cancer. The chemotherapy efficacy of CEA and CA125 have good consistencies with CT.

Key words: Carcinoembryonic antigen, Neuron specific enolase, Carbohydrate antigen 125, Cytokeratin-19-fragment, Lung cancer