Abstract:

Objective To investigate the composition and drug resistance of respiratory infection pathogens in patients with lung cancer after chemotherapy,and to provide a reference for clinical treatment. Methods The pathogens were isolated from 170 respiratory infection patients with lung cancer after chemotherapy from January 2015 to April 2020,and drug susceptibility test was conducted. Results Among the 202 non-repetitive isolates,127（62.9%）isolates were Gram-negative bacteria. The top 3 pathogens were Pseudomonas aeruginosa（35 isolates,17.3%）,Acinetobacter baumannii（28 isolates,13.9%） and Klebsiella pneumoniae（26 isolates,12.9%）. There were 56（27.7%） isolates of Gram-positive bacteria,of which the detection rate of Staphylococcus aureus was the highest（35 isolates,17.3%）. There were 19（9.4%） isolates of fungi. Drug susceptibility test showed that Pseudomonas aeruginosa,Acinetobacter baumannii and Klebsiella pneumoniae had drug resistance rate to carbapenems（22.8%,40.7% and 3.8%,respectively）. The drug resistance rate of Staphylococcus aureus to penicillin was 88.6%. Gram-positive bacteria were not yet resistant to vancomycin and linezolid. The detection rate of methicillin-resistant Staphylococcus aureus（MRSA） was 28.6%. Conclusions The main pathogens isolated from respiratory infection patients with lung cancer after chemotherapy are Gram-negative bacteria,and the drug resistance is serious. Rational drugs should be used in clinic.

Key words: Lung cancer, Chemotherapy, Respiratory infection, Pathogen, Drug resistance