Abstract:

Objective To investigate the roles of single and combined determinations of serum human chorionic gonadotropin（β-HCG） ratio,progesterone and endometrial thickness for predicting ectopic pregnancy. Methods A total of 300 suspected patients with ectopic pregnancy were enrolled,they were proved to be ectopic pregnancy or intrauterine pregnancy later,and their clinical data were analyzed retrospectively. Receiver operating characteristic（ROC） curve and Logistic regression equation were used to analyze the roles of serum β-HCG ratio,progesterone and endometrial thickness determinations for predicting ectopic pregnancy. The predictive cut-off value of each index was determined,and the sensitivity and specificity of each index of single and combined determinations were evaluated. Results Serum β-HCG ratio,progesterone and endometrial thickness in ectopic pregnancy group were lower than those in normal pregnancy group（P<0.001）. The single determinations of serum β-HCG ratio,progesterone and endometrial thickness were valuable for the prediction of ectopic pregnancy. When the cut-off value of progesterone was 55.3 nmol/L,the sensitivity was 90.4%,and the specificity was 78.6%. When the cut-off value of serum β-HCG ratio was 2.01,the sensitivity was 86.5%,and the specificity was 83.9%. When the cut-off value of endometrial thickness was 11.5 mm,the sensitivity was 86.5%,and the specificity was 60.7%. The sensitivity of the combined determination was 94.6%,and the specificity was 88.5%. The areas under the ROC curves of single and combined determinations were 0.852 for the determination of serum β-HCG ratio,0.845 for the determination of progesterone,0.736 for the determination of endometrial thickness,0.887 for the combined determination of progesterone and endometrial thickness,0.868 for the combined determination of serum β-HCG ratio and progesterone,0.867 for the combined determination of serum β-HCG ratio and endometrial thickness and 0.950 for the combined determination of 3 indices. Conclusions The combined determination of serum β-HCG ratio, progesterone and endometrial thickness for predicting ectopic pregnancy has good efficiency than that of any single determination for the early diagnosis of ectopic pregnancy.

Key words: Human chorionic gonadotropin, Progesterone, Endometrial thickness, Ectopic pregnancy