Tumor markers for the combined screening of female genital tract cancer and breast cancer

doi:10.3969/j.issn.1673-8640.2018.06.011

Abstract

Abstract:

Objective To investigate the diagnostic role of the combined determination of serum alpha fetoprotein（AFP）,carcinoembryonic antigen（CEA）,carbohydrate antigen 199（CA199）,carbohydrate antigen 153（CA153）and carbohydrate antigen 125（CA125） in female genital tract cancer and breast cancer. Methods Totally,55 female genital tract cancer and breast cancer patients,55 benign inflammatory patients and 55 healthy subjects were enrolled. Serum levels of AFP,CEA,CA199,CA153 and CA125 were determined,and the results were analyzed statistically. The sensitivities and specificities of the 5 markers for the diagnosis of female genital tract cancer and breast cancer were compared. Results The levels of AFP,CEA,CA199,CA153 and CA125 in cancer group were higher than those in benign inflammatory and healthy control groups（P<0.05）. The sensitivity and specificity of the combined determination of the 5 markers were higher than those of the single determinations. Conclusions The combined determination of the 5 markers has a diagnostic value in the screening of female genital tract cancer and breast cancer,and it is helpful for early screening and early diagnosis.

Key words: Tumor marker, Female genital tract cancer, Breast cancer, Chemiluminescence

CLC Number:

R446.62

WU Yongchun. Tumor markers for the combined screening of female genital tract cancer and breast cancer[J]. Laboratory Medicine, 2018, 33(6): 512-515.

Figures/Tables 4

References 14

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组别	例数	AFP（ng/mL）	CEA（ng/mL）	CA199（U/mL）	CA153（U/mL）	CA125（U/mL）
癌症组	55	65.46±14.23^*	120.31±15.6^*	221.64±15.86^*	215.37±17.31^*	258.43±18.35^*
良性炎症组	55	8.95±3.37^#	2.95±1.04^#	45.37±12.63^#	56.48±10.46^#	41.29±8.71^#
健康普查组	55	3.57±1.27	1.97±0.73	13.58±7.26	22.49±5.47	2.53±0.92
F值		4.23	5.22	6.12	6.75	5.94
P值		<0.05	<0.05	<0.05	<0.05	<0.05

组别	例数	AFP（ng/mL）	CEA（ng/mL）	CA199（U/mL）	CA153（U/mL）	CA125（U/mL）
癌症组	55	65.46±14.23^*	120.31±15.6^*	221.64±15.86^*	215.37±17.31^*	258.43±18.35^*
良性炎症组	55	8.95±3.37^#	2.95±1.04^#	45.37±12.63^#	56.48±10.46^#	41.29±8.71^#
健康普查组	55	3.57±1.27	1.97±0.73	13.58±7.26	22.49±5.47	2.53±0.92
F值		4.23	5.22	6.12	6.75	5.94
P值		<0.05	<0.05	<0.05	<0.05	<0.05

项目	AFP	CEA	CA199	CA153	CA125	联合检测
敏感性	30.18	72.56	65.41	72.35	86.47	83.28
特异性	40.12	62.13	60.78	76.89	90.15	82.36

项目	AFP	CEA	CA199	CA153	CA125	联合检测
敏感性	30.18	72.56	65.41	72.35	86.47	83.28
特异性	40.12	62.13	60.78	76.89	90.15	82.36

项目	AFP	CEA	CA199	CA153	CA125	联合检测
敏感性	32.14	76.32	64.45	85.67	71.47	87.49
特异性	39.21	70.66	62.84	88.43	70.15	89.65