Serum TPOAb and TgAb levels in Hashimoto's thyroiditis patients and their correlations with disease severity

doi:10.3969/j.issn.1673-8640.2018.10.007

Abstract

Abstract:

Objective To investigate the correlations of serum anti-thyroid peroxidase antibody（TPOAb） and thyroid-globulin antibody（TgAb） levels in Hashimoto's thyroiditis（HT） patients with disease severity. Methods A total of 80 HT patients were enrolled as HT group,and 50 healthy subjects were enrolled as healthy control group. The levels of serum TPOAb and TgAb were determined. They were further classified into high TPOAb group（40 cases）,low TPOAb group（40 cases）,high TgAb group（40 cases） and low TgAb group（40 cases） according to TPOAb and TgAb medians. Serum thyroid function indices [thyroid-stimulating hormone（TSH）,free triiodothyronine（FT₃） and free thyroxine（FT₄）],T helper cell（Th） 1 [interferon gamma（IFN-γ） and interleukin（IL）-2 and Th2（IL-4 and IL-13）] were determined in HT group. Results Serum TPOAb and TgAb levels in HT group were higher than those in healthy control group（P<0.05）. Serum TSH in high TPOAb group and high TgAb group were higher than those in low TPOAb group and low TgAb group,and FT₃ and FT₄ were lower than those in low TPOAb group and low TgAb group. Serum IFN-γ and IL-2 in high TPOAb group and high TgAb group were higher than those in low TPOAb group and low TgAb group. Serum IL-4 and IL-13 were lower than those in low TPOAb group and low TgAb group （P<0.05）. Conclusions TPOAb and TgAb have high expressions in HT patients,and there are relations of TPOAb and TgAb levels with thyroid damage degree and Th1/Th2 immune disorder degree,which can reflect the severity of disease.

Key words: Anti-thyroid peroxidase antibody, Thyroid-globulin antibody, Thyroid function, T helper cell, Hashimoto's thyroiditis

CLC Number:

R446.62

ZHU Xudong. Serum TPOAb and TgAb levels in Hashimoto's thyroiditis patients and their correlations with disease severity[J]. Laboratory Medicine, 2018, 33(10): 903-906.

Figures/Tables 5

References 12

[1]	LEE M N,LEE S Y,HUR K Y,et al.Thyroxine(T4) autoantibody interference of free T4 concentration measurement in a patient with Hashimoto's thyroiditis[J]. Ann Lab Med,2017,37(2):169-171.
[2]	RUGGERI R M,TRIMARCHI F,GIUFFRIDA G,et al.Autoimmune comorbidities in Hashimoto's thyroiditis:different patterns of association in adulthood and childhood/adolescence[J]. Eur J Endocrinol,2017,176(2):133-141.
[3]	金宝生,樊卫,祁金友. 血清中TPOAb和TgAb的升高对甲状腺疾病进展的影响[J]. 国际检验医学杂志,2014,35(24):3433-3436.
[4]	马倩倩,梁秋华,孙琳,等. 桥本氏甲状腺炎患者外周血中CD4+CD45 RO+记忆性T细胞的表达及意义[J]. 中国免疫学杂志,2016,32(10):1527-1531.
[5]	GONG Q,LI X,GONG Q,et al.Hashimoto's thyroiditis could be secondary to vitiligo:the possibility of antigen crossover and oxidative stress between the two diseases[J]. Arch Dermatol Res,2016,308(4):277-281.
[6]	曾慧妍,赵玲,王璟霖,等. 金水宝胶囊对桥本氏甲状腺炎自身抗体的影响及量效关系[J]. 广州中医药大学学报,2014,31(3):357-360.
[7]	GABALEC F,SRBOVA L,NOVA M,et al.Impact of Hashimoto's thyroiditis,TSH levels,and anti-thyroid antibody positivity on differentiated thyroid carcinoma incidence[J]. Endokrynol Pol,2016,67(1):48-53.
[8]	张育瑛,夏鸣喆,李艺,等. 隔附子饼灸对桥本氏甲状腺炎血清特异抗体与甲状腺功能的相关性分析[J]. 上海针灸杂志,2013,32(1):25-27.
[9]	ASIK M,GUNES F,BINNETOGLU E,et al.Decrease in TSH levels after lactose restriction in Hashimoto's thyroiditis patients with lactose intolerance[J]. Endocrine,2014,46(2):279-284.
[10]	QIN Q,LIU P,LIU L,et al.The increased but non-predominant expression of Th17- and Th1-specific cytokines in Hashimoto's thyroiditis but not in Graves' disease[J]. Braz J Med Biol Res,2012,45(12):1202-1208.
[11]	ZHANG K,WANG Y,MA W,et al.Genistein improves thyroid function in Hashimoto's thyroiditis patients through regulating Th1 cytokines[J]. Immunobiology,2017,222(2):183-187.
[12]	盛建国,王斌,曹昆昆,等. 桥本氏甲状腺炎患者甲状腺超声弹性对比指数与血清自身抗体、Th1/Th2型细胞因子含量的关系[J]. 海南医学院学报,2016,22(19):2357-2360.

组别	例数	TPOAb	TgAb
HT组	80	394.72±54.82^*	193.26±25.17^*
正常对照组	50	1.73±0.29	0.97±0.11

组别	例数	TPOAb	TgAb
HT组	80	394.72±54.82^*	193.26±25.17^*
正常对照组	50	1.73±0.29	0.97±0.11

组别	例数	TSH （mU/L）	FT₃ （pmol/L）	FT₄ （pmol/L）
高TPOAb组	40	32.63±4.56^*	2.27±0.38^*	6.75±0.97^*
低TPOAb组	40	14.17±1.88	3.42±0.45	13.15±1.76

组别	例数	TSH （mU/L）	FT₃ （pmol/L）	FT₄ （pmol/L）
高TPOAb组	40	32.63±4.56^*	2.27±0.38^*	6.75±0.97^*
低TPOAb组	40	14.17±1.88	3.42±0.45	13.15±1.76

组别	例数	Th1细胞因子		Th2细胞因子
组别	例数	IFN-γ（ng/L）	IL-2（μg/L）	IL-4（ng/L）	IL-13（ng/L）
高TPOAb组	40	251.28±30.49^*	12.64±1.88^*	115.47±16.83^*	59.27±7.18^*
低TPOAb组	40	178.66±23.75	9.17±0.98	163.88±20.75	81.66±9.05