Research progress on the relationship between interleukin gene polymorphisms and gastric cancer

doi:10.3969/j.issn.1673-8640.2022.09.018

Abstract

Abstract:

Interleukins（IL） are common inflammatory cytokines that can drive a variety of cellular processes including metastasis,infiltration,growth and angiogenesis of tumor cells by paracrine and autocrine means. Gastric cancer is a type of gastrointestinal malignancy that is difficult to diagnose at an early stage,and its development is related to a variety of factors. Recent genetic studies have revealed that many single nucleotide polymorphism（SNP） loci in cytokine-encoding genes are related with the development of various cancers and diseases,suggesting that IL gene polymorphisms may play roles in the occurrence,development and metastasis of gastric cancer,and it is associated with the risk and susceptibility of gastric cancer development. Theoretically,the study of IL gene polymorphisms can be used to find gastric cancer-related diagnostic and treatment targets and elucidate the regulatory mechanisms of IL genes in gastric cancer,providing a new reference for its clinical diagnosis and treatment. This review focuses on the correlation of IL gene polymorphisms of gastric cancer and its research progress.

Key words: Interleukin, Gene polymorphism, Gastric cancer

CLC Number:

R446.1

NIE Tian, RAN Zihan, JIN Lei. Research progress on the relationship between interleukin gene polymorphisms and gastric cancer[J]. Laboratory Medicine, 2022, 37(9): 882-886.

References 40

[1]	张梦青, 宋光. 基因多态性与胃癌的相关性研究[J]. 胃肠病学和肝病学杂志, 2019, 28(1):108-111.
[2]	王杨阳, 张逸寅, 顾康生. 炎性细胞因子与胃癌关系的研究进展[J]. 临床肿瘤学杂志, 2020, 25(5):466-471.
[3]	冯宁, 尚红港. 肿瘤坏死因子-α、白介素-6和白介素-8检测在胃癌中的临床价值[J]. 肿瘤基础与临床, 2021, 34(3):244-247.
[4]	LAU H K, HSIEH M J, YANG S F, et al. Association between interleukin-18 polymorphisms and hepatocellular carcinoma occurrence and clinical progression[J]. Int J Med Sci, 2016, 13(7):556-561. DOI URL
[5]	金磊, 陈宁, 吴洁敏, 等. 白细胞介素4基因多态性与脑梗死的关系[J]. 诊断学理论与实践, 2015, 14(6):554-559.
[6]	孙瑞营, 李洋, 赵旭, 等. 胃癌患者血清中胃癌相关细胞因子检测及其在胃癌诊断中的应用价值[J]. 吉林大学学报(医学版), 2020, 46(6):1274-1282.
[7]	EINI P, MAJZOOBI M M, GHASEMI BASIR H R, et al. Comparison of the serum level of interleukin-4 in patients with brucellosis and healthy controls[J]. J Clin Lab Anal, 2020, 34(7):e23267.
[8]	COX A A, SAGOT Y, HEDOU G, et al. Low-dose pulsatile interleukin-6 as a treatment option for diabetic peripheral neuropathy[J]. Front Endocrinol(Lausanne), 2017, 8:89.
[9]	BANUELOS J, LU N Z. A gradient of glucocorticoid sensitivity among helper T cell cytokines[J]. Cytokine Growth Factor Rev, 2016, 31:27-35. DOI URL
[10]	KWANIAK K, CZARNIK-KWANIAK J, MAZIARZ A, et al. Scientific reports concerning the impact of interleukin 4,interleukin 10 and transforming growth factor β on cancer cells[J]. Cent Eur J Immunol, 2019, 44(2):190-200.
[11]	吴少锋. IL4和IL6基因多态性与胃癌风险的相关性研究[J]. 解放军预防医学杂志, 2018, 36(3):386-389.
[12]	郭欣, 李云婷, 郝冀洪, 等. 白细胞介素4 rs2070874基因多态性与H. pylori感染及胃癌易感性的关系[J]. 河北医科大学学报, 2018, 39(12):1455-1459.
[13]	陈广源, 胡聪, 张依玲, 等. IL-4 rs2243250基因多态性与胃癌发病关联的Meta分析[J]. 南昌大学学报(医学版), 2020, 60(5):64-69.
[14]	陈锦霞, 单保恩, 李清靖, 等. IL-17及其相关分子在胃癌组织中的表达和相关性分析[J]. 肿瘤学杂志, 2019, 25(6):537-540.
[15]	黄萍, 徐洪雨. 白细胞介素-6在胃癌诊断、发展、治疗中的作用[J]. 胃肠病学和肝病学杂志, 2021, 30(2):207-211.
[16]	HARUN-OR-ROSHID M, ALI M B, JESMIN, et al. Statistical meta-analysis to investigate the association between the interleukin-6(IL-6) gene polymorphisms and cancer risk[J]. PLoS One, 2021, 16(3):e0247055. DOI URL
[17]	FISHMAN D, FAULDS G, JEFFERY R, et al. The effect of novel polymorphisms in the interleukin-6(IL-6) gene on IL-6 transcription and plasma IL-6 levels,and an association with systemic-onset juvenile chronic arthritis[J]. J Clin Invest, 1998, 102(7):1369-1376. DOI URL
[18]	刘满想. IL-6-174C/G基因多态性与胃癌易感性的meta分析[D]. 兰州: 兰州大学, 2018.
[19]	王昆龄, 陈凡, 王晓莉. 白细胞介素-6与胃癌易感性的相关关系[J]. 现代预防医学, 2014, 41(18):3450-3452.
[20]	HE B, PAN B, PAN Y, et al. IL-4/IL-4R and IL-6/IL-6R genetic variations and gastric cancer risk in the Chinese population[J]. Am J Transl Res, 2019, 11(6):3698-3706.
[21]	冯婧, 李新胜, 侯振江. Th17细胞分化与调控的研究进展[J]. 中国免疫学杂志, 2021, 37(13):1648-1655.
[22]	王月珍. 七氟烷与丙泊酚麻醉对胃癌根治术患者肝肾功能及炎症因子的影响[J]. 国际免疫学杂志, 2018, 41(2):247-250.
[23]	HADIAN Y, BAGOOD M D, DAHLE S E, et al. Interleukin-17:potential target for chronic wounds[J]. Mediators Inflamm, 2019, 2019:1297675.
[24]	FENG S, YU H, YU Y, et al. Levels of inflammatory cytokines IL-1β,IL-6,IL-8,IL-17A,and TNF-α in aqueous humour of patients with diabetic retinopathy[J]. J Diabetes Res, 2018, 2018:8546423.
[25]	侯晶晶. 胃癌患者外周血Th17细胞相关因子检测及其临床意义[J]. 现代诊断与治疗, 2020, 31(6):960-961.
[26]	李春波, 苏韫, 龚红霞, 等. IL-17通过NF-κB信号通路参与胃癌发生发展的免疫调控[J]. 基础医学与临床, 2020, 40(7):923-928.
[27]	陈锦霞, 单保恩, 李清靖, 等. IL-17及其相关分子在胃癌组织中的表达和相关性分析[J]. 肿瘤学杂志, 2019, 25(6):537-540.
[28]	MENG X Y, ZHOU C H, MA J, et al. Expression of interleukin-17 and its clinical significance in gastric cancer patients[J]. Med Oncol, 2012, 29(5):3024-3028. DOI PMID
[29]	ZHANG X, ZHENG L, SUN Y, et al. Analysis of the association of interleukin-17 gene polymorphisms with gastric cancer risk and interaction with Helicobacter pylori infection in a Chinese population[J]. Tumour Biol, 2014, 35(2):1575-1580. DOI URL
[30]	殷珍珍, 王晓燕, 姜相君. IL-17基因多态性与胃癌易感性的关系[J]. 中国癌症防治杂志, 2017, 9(1):50-54.
[31]	HE B, PAN B, PAN Y, et al. Polymorphisms of IL-23R predict survival of gastric cancer patients in a Chinese population[J]. Cytokine, 2019, 117:79-83. DOI PMID
[32]	GAO J F, ZHANG H, LV J, et al. Associations of the IL-17A rs2275913 and IL-17F rs763780 polymorphisms with the risk of digestive system neoplasms:a meta-analysis[J]. Int Immunopharmacol, 2019, 67:248-259. DOI URL
[33]	CHEN L, LI X G, WANG J F, et al. Potential effects of IL-17A rs2275913 and IL-17F rs763780 polymorphisms on susceptibility to gastric cancer in Chinese population:a meta-analysis[J]. Eur Rev Med Pharmacol Sci, 2020, 24(7):3633-3641.
[34]	HU Y, XU D, XIA H, et al. Associations of IL-17A-197G/A and IL-17F 7488T/C polymorphisms with cancer risk in asians:an updated meta-analysis from 43 studies[J]. Gene, 2021, 804:145901. DOI URL
[35]	孙梦瑶, 吴秋雪, 蔡思, 等. 白介素22在消化系统恶性肿瘤发生发展中的作用[J]. 中华检验医学杂志, 2018, 41(10):720-723.
[36]	王荣, 覃海媚, 陆玉兰, 等. 白细胞介素-22基因多态性的研究进展[J]. 右江医学, 2017, 45(6):728-731.
[37]	LIAO F, HSU Y C, KUO S H, et al. Genetic polymorphisms and tissue expression of interleukin-22 associated with risk and therapeutic response of gastric mucosa-associated lymphoid tissue lymphoma[J]. Blood Cancer J, 2014, 4(10):eXX.
[38]	QIN S Y, YANG X W, LUO W, et al. Association of interleukin 22 polymorphisms with gastric cancer risk[J]. Tumour Biol, 2015, 36(3):2033-2039. DOI URL
[39]	WANG Y M, LI Z X, TANG F B, et al. Association of genetic polymorphisms of interleukins with gastric cancer and precancerous gastric lesions in a high-risk Chinese population[J]. Tumour Biol, 2016, 37(2):2233-2242. DOI URL
[40]	CHAI L L, XIAO Y X, MENG L H, et al. The rs2227481 C>T polymorphism in the IL22 gene promoter significantly reduces the risk of liver,lung,and gastric cancer in a Han Chinese population[J]. Biomed Environ Sci, 2021, 34(7):572-576.