›› 2013, Vol. 28 ›› Issue (6): 475-478.DOI: 10.3969/j.issn.1673-8640.2013.06.005

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Predictive significance of parathyroid hormone determination in patients with hypocalcemia after total thyroidectomy

  

  1. 1. Department of Otolaryngology Head and Neck Surgery,Peking University Civil Aviation Clinical Medical College,Civil Aviation General Hospital,Beijing 100123,China; 2. Department of Otolaryngology,Beijing Youan Hospital,Capital Medical University,Beijing 100041,China
  • Received:2012-04-20 Revised:2012-12-17 Online:2013-06-30 Published:2013-06-11

Abstract: Objective To investigate the early predictive significance of serum 1 h intact parathyroid hormone(1h-iPTH)determination in patients with hypocalcemia after total thyroidectomy. Methods A total of 103 patients undergoing total thyroidectomy were enrolled,and 1h-iPTH and serum 24 h corrected calcium(24h-cCa)levels were determined after total thyroidectomy 1 h and 24 h. Results Among the 103 patients undergoing total thyroidectomy,the incidence of postoperative hypocalcemia was 37.9%(39/103),and the 1h-iPTH level in patients with hypocalcemia was lower than that in patients with normocalcemia(P<0.01). The incidence of hypocalcemia in patients with 1h-iPTH <16 pg/mL was higher than that in patients with 1 h-iPTH≥16 pg/mL(P<0.01). When 1h-iPTH<16 pg/mL was as a predictor for hypocalcemia,the sensitivity,specificity and accuracy were 82.1%,90.6% and 87.4%,respectively. Conclusions 1h-iPTH after total thyroidectomy shows a strong correlation with postoperative hypocalcemia,and could be as an indicator for diagnosing hypocalcemia.

Key words: Parathyroid hormone, Hypocalcemia, Thyroidectomy