The relationship of plasma Lp-PLA2 level with the stability of carotid artery atherosclerotic plaque and the severity of neurological impairment in patients with acute ischemic stroke

doi:10.3969/j.issn.1673-8640.2013.10.005

Abstract

Abstract:

Objective To investigate the relationship of plasma lipoprotein-associated phospholipase A2(Lp-PLA2) level with the stability of carotid artery atherosclerotic plaque and the severity of neurological impairment in patients with acute ischemic stroke. Methods According to the results of cervical vascular color Doppler ultrasound examination,106 patients with acute ischemic stroke were classified into unstable plaque group(44 cases),stable plaque group(38 cases)and non-plaque group(24 cases). A total of 40 healthy subjects were enrolled as healthy controls. Plasma Lp-PLA2 levels were determined by enzyme-linked immunosorbent assay (ELISA),and the severity of neurological impairment were assessed by the National Institute of Health Stroke Scale(NIHSS) score. Results Compared with the healthy controls,the level of plasma Lp-PLA2 was significantly higher in patients with acute ischemic stroke (Z=-6.995,P<0.05). Plasma levels of Lp-PLA2 in stable plaque group and unstable plaque group were significantly higher than those in non-plaque group with statistical significance (Z=-5.670,P<0.05). Plasma levels of Lp-PLA2 in unstable plaque group were significantly higher than those in stable plaque group with statistical significance (Z=-6.185,P<0.05). According to the results of receiver operating characteristic (ROC) curve,the best cut-off value of Lp-PLA2 was 137.00 μg/L. The sensitivity was 81.8%, and the specificity was 95.1%. The severity of neurological impairment increased with the levels of plasma Lp- PLA2(χ²=74.233,P<0.05). The NIHSS score was positively correlated with the levels of plasma Lp-PLA2(r_s=0.861,P<0.05). Conclusions The level of plasma Lp-PLA2 is related to the stability of carotid artery atherosclerotic plaque and the severity of neurological impairment in patients with acute ischemic stroke. Plasma Lp-PLA2 can serve as a predictive indicator of carotid artery atherosclerotic plaque stability.Meanwhile,it plays an important role in monitoring the conditions of patients with acute ischemic stroke.

Key words: Lipoprotein-associated phospholipase A2, Ischemic stroke, Plaque stability

CLC Number:

Q556

LONG Lu,WANG Zhongming,CHEN Zhen,TAO Ya,WANG Kun, YI Bin.. The relationship of plasma Lp-PLA2 level with the stability of carotid artery atherosclerotic plaque and the severity of neurological impairment in patients with acute ischemic stroke[J]. , 2013, 28(10): 885-889.

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