Abstract:

Objective To investigate the relationship between serum free fatty acid （FFA）and non-insulin-dependent diabetes mellitus （NIDDM） metabolic disorder. Methods A total of 625 patients with NIDDM and 283 healthy subjects were enrolled,and serum FFA,total cholesterol （TC）,triglyceride （TG）,high-density lipoprotein cholesterol （HDL-C）,low-density lipoprotein cholesterol （LDL-C）,apolipoprotein （apo） A1,apo B100,lipoprotein [Lp（a）],homocysteine （Hcy）,glucose（Glu）,glycated hemoglobin A_1c（HbA_1c）,uric acid（UA）,creatinine（Cr）,urea,cystatin C（Cys C）and alanine aminotransferase（ALT） were determined. NIDDM patients were classified into new-diagnosed NIDDM group（47 cases）,stable group（545 cases） and unstable group （33 cases）. Results There was statistical significance for these parameters between newly-diagnosed NIDDM and healthy control groups （P<0.05）. There was statistical significance for FFA,Lp（a）,apo A1,apo B100,LDL-C,HDL-C,Glu,ALT,HbA_1c and UA between unstable and healthy control groups （P<0.01）. There was statistical significance for HDL-C,apo A1,LDL-C,apo B100,FFA,Lp（a）,Glu,ALT,HbA_1c and UA between stable and healthy control groups（P<0.05）,and there was no statistical significance for other parameters compared with healthy control group （P>0.05）. Conclusions The levels of FFA and blood lipid in NIDDM patients have a correlation with metabolic disorder.

Key words: Free fatty acid, Blood lipid, Non-insulin-dependent diabetes mellitus