Abstract:

Objective To determine the levels of D-dimer （DD）,fibrin（fibrinogen）degradation products（FDP）and antithrombin（AT）in healthy pregnant women with different periods of pregnancy,and to establish the gestational week-specific reference ranges of DD,FDP and AT by continuous follow-up determinations. Methods A total of 90 non-pregnant women were enrolled as control group,and 140 healthy pregnant women were enrolled. In early pregnancy （<21 gestational weeks） and late pregnancy （>32 gestational weeks）,the levels of plasma DD and FDP were determined by immunoturbidimetry,and the levels of AT were determined by chromogenic substrate method. Results The levels of plasma DD,FDP and AT in pregnant women were not related to ages. The levels of plasma DD and FDP in late pregnancy group were higher than those in early pregnancy group（P<0.05） and control group （P<0.05）. There was no statistical significance for the levels of AT in late pregnancy group compared with those in early pregnancy and control groups （P>0.05）. The reference ranges of plasma DD,FDP and AT in early pregnancy were <0.92 mg/L,<6.00 mg/L and 70%-125%. The reference ranges of plasma DD,FDP and AT in late pregnancy were <4.14 mg/L,<13.83 mg/L and 70%-125%. Conclusions The levels of plasma DD and FDP in pregnant women increase with gestational weeks,and are not related to ages,but there was no change for the levels of AT. The reference ranges of plasma DD,FDP and AT in early and late pregnancy have been established preliminarily.

Key words: D-dimer, Fibrin（fibrinogen）degradation products, Antithrombin, Pregnant women