Abstract: Objective To observe the activity changes of alpha-L-fucosidase (AFU), alkaline phosphatase (ALP) and adenosine deaminase (ADA) in pregnant women and their correlations with pregnant period. Methods The activities of AFU, ALP and ADA were determined in 352 pregnant women (210 cases with early-stage pregnancy and 142 cases with late-stage pregnancy) and 322 unpregnant women. Dynamic monitoring was performed (early-stage pregnancy for 14th, 22nd, 30th and 38th weeks, late-stage pregnancy for 38th and 40th weeks and unpregnancy for 8th and 24th weeks after visiting). Resutls ALP and AFU were higher in pregnant group than in unpregnant group (P=0.000). The ADA in unpregnant group was higher than that in pregnant group (P=0.000). ALP and AFU in late-stage pregnancy group were higher than those in early-stage pregnancy group (P=0.000), but there was no statistical significance for ADA between the 2 groups (P>0.05). The dynamic monitoring for early-stage pregnancy group showed that AFU and ALP increased with the pregnancy, but there was no change for ADA. There was no statistical significance of AFU, ALP and ADA in late-stage pregnancy group between the 38th week and the 40th week (P>0.05). Dynamic monitoring showed that ALP and ADA in 8th week after visiting were different from the beginning (P=0.000), and there was statistical significance for ADA in the 24th week after visiting. Compared with the 8th week after visiting, there were statistical significance for ALP, AFU and ADA in the 24th week after visiting(P<0.05). Conclusions The serum AFU and ALP in pregnant women increase significantly, and there is relationship with pregnancy.

Key words: Alpha-L-fucosidase, Alkaline phosphatase, Adenosine deaminase, Pregnancy