Abstract:

Objective To investigate the changes and roles of serum exosomes,placental exosomes [placental alkaline phosphatase（PLAP）] and exosomal microRNA-210（miR-210） in pregnant women during preeclampsia（PE） pregnancy. Methods Totally,30 patients with PE and 30 healthy pregnant women were enrolled. All serum samples were collected in the first trimester,the second trimester and the third trimester of pregnancy. The amount of serum exosomes,the level of PLAP and the expression of exosomal miR-210 were determined. The correlation between PLAP and miR-210 was analyzed using Pearson analysis. Results The amount of serum exosomes,the level of PLAP and miR-210 were increased with the progress of pregnancy. Compared with healthy pregnant women,the amount of serum exosomes,the level of PLAP and miR-210 in PE group were higher in different trimesters of pregnancy（P<0.05）. The correlation between the level of PLAP and exosomal miR-210 was positive（r=0.668,P<0.01）. Conclusions The amount of serum exosomes,the level of PLAP and exosomal miR-210 in PE group change from the first trimester of pregnancy,and they play roles in the early prediction and diagnosis of PE.

Key words: Exosome, Placental alkaline phosphatase, MicroRNA-210, Preeclampsia