Research progress of exosomes in gastrointestinal cancer metastasis

doi:10.3969/j.issn.1673-8640.2020.12.004

Abstract

Abstract:

Exosomes are sorts of small extracellular vesicles ranging approximately from 30 nm to 100 nm in diameter,which can serve as carriers transporting protein,microRNA（miRNA）,long non-coding RNA（lncRNA） and others to target cells,further mediating cell communication. Gastrointestinal cancer is a malignant cancer with high morbidity and mortality,and cancer metastasis is the main cause of death. Exosome play a key role in the process of gastrointestinal cancer metastasis by targeting epithelial-mesenchymal transition,angiogenesis,tumor microenvironment and so on. This review summarizes the role of exosomes in regulating epithelial-mesenchymal transition,angiogenesis and tumor microenvironment,which may provide new ideas for the study of gastrointestinal cancer metastasis.

Key words: Exosome, Gastrointestinal cancer, Metastasis

CLC Number:

R446.1

CHEN Jia, JIN Wei, HU Xiaobo. Research progress of exosomes in gastrointestinal cancer metastasis[J]. Laboratory Medicine, 2020, 35(12): 1220-1223.

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