Research progress on the role of estrogen receptor in osteosarcoma

doi:10.3969/j.issn.1673-8640.2022.04.003

Abstract

Abstract:

Estrogen receptor（ER） belongs to the nuclear receptor superfamily,which mainly binds with the ligand estrogen to activate transcription of its target genes. The interaction of ER with estrogen could actively recruit co-regulator factors to influence transcription of ER-dependent genes. ER not only plays a role in promoting sexual organ maturation,parasexual development and maintaining sexual function,but also participates in the regulation of tumor cell growth,drug resistance,epithelial-mesenchymal transformation（EMT） and metastasis during the occurrence and development of tumors. ER is expressed at a low level in osteosarcoma. Regulating the expression level or activity of ER can effectively change the expression of estrogen/ER-dependent transcription factors and affect the invasion,metastasis,drug sensitivity and growth characteristics of tumors. This review focuses on the research progress of ER in the occurrence,development and treatment of osteosarcoma in the recent years,trying to provide new insights for clinic.

Key words: Estrogen receptor, Osteosarcoma, Metastasis, Drug resistance, Epithelial-mesenchymal transformation

CLC Number:

R446.62

SUN Xiaodan, LIU Yiwen, HE Yiqing, DU Yan, ZHANG Guoliang, GAO Feng, YANG Cuixia. Research progress on the role of estrogen receptor in osteosarcoma[J]. Laboratory Medicine, 2022, 37(4): 313-318.

Figures/Tables 3

References 51

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项目	机制	功能	参考文献
ERα	通过碱性磷酸酶降低波形蛋白、MMP9的蛋白表达水平	抑制转移	^[10]
	通过碱性磷酸酶抑制SOX2、OCT4、NANOG基因表达	减弱细胞干性	^[10]
ERβ	激活Wnt信号通路,降低MMP7、MMP9的表达水平	诱导凋亡	^[28]
	激活NF-κB/BCL-2使自噬标志物LC3-Ⅱ表达增加	诱导自噬	^[35]
	抑制PI3K/Akt	诱导凋亡	^[39]
GPER	介导snail的翻译后调控	抑制转移	^[15]
	通过MAPK信号通路降低IL-6 mRNA的稳定性	抑制侵袭转移	^[13]

项目	机制	功能	参考文献
ERα	通过碱性磷酸酶降低波形蛋白、MMP9的蛋白表达水平	抑制转移	^[10]
	通过碱性磷酸酶抑制SOX2、OCT4、NANOG基因表达	减弱细胞干性	^[10]
ERβ	激活Wnt信号通路,降低MMP7、MMP9的表达水平	诱导凋亡	^[28]
	激活NF-κB/BCL-2使自噬标志物LC3-Ⅱ表达增加	诱导自噬	^[35]
	抑制PI3K/Akt	诱导凋亡	^[39]
GPER	介导snail的翻译后调控	抑制转移	^[15]
	通过MAPK信号通路降低IL-6 mRNA的稳定性	抑制侵袭转移	^[13]