Research progress of exosomes in tumor diagnosis

doi:10.3969/j.issn.1673-8640.2018.12.021

Abstract

Abstract:

Exosomes are nanoscale vesicle with a double lipid membrane structure,which contain a broad array of biologically active materials,including microRNA（miRNA）,mRNA,DNA fragments and functional proteins. Exosomes can be secreted by almost all types of cells and widely distributed in serum,saliva,urine and other body fluids. Recently,tumor-derived exosomes have close relationship with tumor progression,and they have the potential of being biomarker in the diagnosis and treatment of tumor. Therefore,the determination and analysis of tumor-derived exosomes can provide a reference for the early diagnosis,treatment assessment and prognosis evaluation of tumors. This review summarizes the research progress of exosomes in tumor diagnosis.

Key words: Exosome, Tumor, Tumor marker, Diagnosis

CLC Number:

R446.1

WANG Qi, WANG Baolong. Research progress of exosomes in tumor diagnosis[J]. Laboratory Medicine, 2018, 33(12): 1148-1152.

Figures/Tables 1

References 44

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肿瘤类型	蛋白标志物	参考文献
胃癌	HER-2/neu、CCR6、CD97	[30-31]
卵巢癌	紧密连接蛋白4、MAGE3/6、 TGF-β1	[32]
胰腺癌	GPC-1、MIF、EGFR	[33-34]
黑色素瘤	CD63、窖蛋白-1	[35]
胶质母细胞瘤	EGFR-vⅢ、TGF-β	[36]

肿瘤类型	蛋白标志物	参考文献
胃癌	HER-2/neu、CCR6、CD97	[30-31]
卵巢癌	紧密连接蛋白4、MAGE3/6、 TGF-β1	[32]
胰腺癌	GPC-1、MIF、EGFR	[33-34]
黑色素瘤	CD63、窖蛋白-1	[35]
胶质母细胞瘤	EGFR-vⅢ、TGF-β	[36]

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