PADI4单核苷酸多态性与类风湿关节炎相关性的Meta分析

检验医学 ›› 2012, Vol. 27 ›› Issue (9): 707-712.

PADI4单核苷酸多态性与类风湿关节炎相关性的Meta分析

许泼实¹,邵凤民¹,孙长义¹,秦望森²,胡宏¹

1. 河南省人民医院检验科，河南郑州 450003；2. 河南省人民医院风湿科，河南郑州 450003

收稿日期:2012-03-23 修回日期:2012-05-08 出版日期:2012-09-12 发布日期:2012-09-12
通讯作者: 许泼实
作者简介:许泼实，1969年生，男，副主任技师，硕士，主要从事临床免疫学的基础与临床应用研究。
基金资助:
河南省科技厅攻关项目（0524410097）

Meta-analysis on the correlation of peptidyl arginine deiminase 4 single nucleotide polymorphisms and rheumatoid arthritis

1. Department of Clinical Laboratory，Henan Provincial People′s Hospital，Henan Zhengzhou 450003，China; 2. Department of Rheumatism，Henan Provincial People′s Hospital，Henan Zhengzhou 450003，China

Received:2012-03-23 Revised:2012-05-08 Online:2012-09-12 Published:2012-09-12

摘要/Abstract

摘要： 目的　探讨肽酰精氨酸脱亚胺基酶4(PADI4)基因单核苷酸多态性与类风湿关节炎(RA)发病风险的关系。方法　采用Meta分析方法对相关研究结论进行合并效应值估计，进行异质性检验、发表偏倚评估和风险比的Meta 分析。结果　共有国内外符合条件的13篇文献纳入分析，累计病例和对照者数分别为11 039例和10 395例。因存在异质性，将PADI4-94研究结果分亚洲人组和欧洲人组进行Meta分析，发现PADI4-94单核苷酸多态性（SNP）与亚洲人种RA风险相关，而与欧洲人种的RA风险无关，综合采用随机效应模式Meta分析时，总体显示PADI4-94与RA风险相关；PADI4-104文献中有一篇存在异质性，排除后经固定效应模式Meta分析显示，PADI4-104 SNP与RA风险存在相关性。发表偏倚评估显示虽有一定的发表偏倚，但剪补法分析显示偏倚不改变相关性结论。结论　PADI4-94和PADI4-104 SNP与RA的发病风险相关。

关键词: 肽酰精氨酸脱亚胺基酶4, 单核苷酸多态性, 关节炎;类风湿, Meta分析

Abstract: Objective　To investigate the relationship between the peptidyl arginine deiminase 4 (PADI4) gene single nucleotide polymorphisms and the risk of rheumatoid arthritis(RA). Methods　Meta-analysis was performed to estimate the pooled odd ratio to assess the risk of RA associated with PADI4 gene polymorphisms. The heterogeneity test，bias evaluation and risk ratio on Meta-analysis were performed. Results　A total of 13 literature studies with 11 039 cases and 10 395 controls were included for Meta-analysis based on criteria. According to heterogeneity test，Asian and European groups were analyzed respectively for PADI4-94 using fixed effect model，and the same model was used to PADI4-104 with one study having heterogeneity. The results of Meta-analysis showed PADI4-94 single nucleotide polymorphisms were associated with the risk of RA for Asian people，but not with that for European people，and PADI4-104 single nucleotide polymorphisms had the high risk of RA for all. Bias analysis confirmed the conclusion by trim and fill method. Conclusions　PADI4-94 and PADI4-104 single nucleotide polymorphisms are associated with the risk of RA.

Key words: Peptidyl arginine deiminase 4, Single nucleotide polymorphism, Rheumatoid arthritis, Meta-analysis

许泼实;邵凤民;孙长义;秦望森;胡　宏. PADI4单核苷酸多态性与类风湿关节炎相关性的Meta分析[J]. 检验医学, 2012, 27(9): 707-712.

XU Poshi;SHAO Fengmin;SUN Changyi;QIN Wangsen;HU Hong . Meta-analysis on the correlation of peptidyl arginine deiminase 4 single nucleotide polymorphisms and rheumatoid arthritis[J]. , 2012, 27(9): 707-712.

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