关键词: α2-HS糖蛋白, 糖尿病, 妊娠, 胰岛素抵抗

Abstract: Objective　To observe the variations of serum levels of alpha 2-HSglycoprotein(AHSG) in pregnant women with different types of glucose intolerance and the correlation with plasma glucose, blood lipid metabolism and insulin resistance. Methods　Totally，135 pregnant women with 36-41 weeks of gestation were classified into 3 groups according to the results of 75 g oral glucose tolerance test(OGTT)：gestational diabetes mellitus(GDM)group: 45cases，gestational impaired glucose tolerance (GIGT)group: 45 cases and normal glucose tolerance (NGT)group:45 cases.The levels of fasting AHSG，fasting plasma glucose (FPG)，fasting insulin(FINS) and fasting blood lipid ［total cholesterol(TC), trigly ceride(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C)］ were measured, and the values of body mass index(BMI),homeostasis model assessment insulin resistance(HOMA-IR) index and hemeostasis model assessment beta (HOMA-β) index were calculated. Results　The serum levels of AHSG in GDM group, GIGT group and NGT group were 150.2±20.0, 131.9 ±16.0 and (124.0±15.0) μg/mL, respectively. There was a statistical significance among the 3 groups（P<0.05）. The levels of FPG，TG，LDL-C and FINS were significantly higher in GDM group than those in NGT group（P<0.05, P<0.01），and the levels of HDLC were significantly lower in GDM group than those in NGT group（P<0.05）. The levels of TG and FINS were significantly higher in GDM group than those in GIGT group（P<0.05, P<0.01），and the levels of TG,LDL-C and FINS were significantly higher in GIGT group than those in NGT group（P<0.05, P<0.01）.The levels of TC had no significant difference among the 3 groups（P>0.05）. The HOMA-IR indices increased gradually, and the HOMA-β indices decreased gradually among the 3 groups with statistical significance (P<0.05).Furthermore，serum AHSG levels had positive relationship with BMI，TG,FINS and HOMAIR ［the coefficients of correlation （r） were 0.406, 0.503, 0.533 and 0.612, P<0.05］,negative relationship with HDL-C and HOMA-β(r=-0.321 and -0.589, P<0.05), and no relationship with FPG and TC(r=0.058, 0.095, P>0.05). Conclusions　AHSG plays an important role in the metabolism of plasma glucose and blood lipid in GDM women, and AHSG is involved in insulin resistance and aggravates the suffering of beta cells. AHSG is closely related with the cause of GDM.

Key words: Alpha 2-HS-glycoprotein, Diabetes mellitus, Gestation, Insulin resistance