Analysis of changes in platelet aggregation rate and D-dimer level in recurrent abortion patients with different times

doi:10.3969/j.issn.1673-8640.2025.03.016

Abstract

Abstract:

Objective To analyze the changes in platelet aggregation rate （PAgT） and D-dimer （D-D） level in recurrent abortion patients with different times，and to provide a reference for early prediction and treatment of recurrent abortion. Methods From July 2020 to August 2023，143 patients with recurrent abortion who were treated in Changzhi People's Hospital were enrolled. They were classified into abortion≥3 time group and 2 time group，which were classified into 2 groups based on their final pregnancy outcome，recurrent abortion group and non-abortion group. PAgT，DD and coagulation function indicators such as fibrinogen （Fib），thrombin time （TT），prothrombin time （PT） and activated partial thromboplastin time （APTT） were determined. The correlation between PAgT，DD level and coagulation function indicators in patients with recurrent abortion was analyzed using Pearson method. The influencing factors of recurrent abortion patients with abortion≥3 times were analyzed using Logistic regression analysis. The predictive value of PAgT and DD level for recurrent abortion was analyzed using receiver operating characteristic （ROC） curve. Results Arachidonic acid （AA） induced PAgT，adenosine diphosphate （ADP） induced PAgT，DD，Fib in≥3 time group were higher than those in 2 time group，while TT，PT，APTT were lower than those in 2 time group （P<0.001）. The levels of AA induced PAgT，ADP induced PAgT，DD in patients with recurrent abortion were positively correlated with Fib，and they were negatively correlated with TT，PT and APTT（P<0.001）. AA induced PAgT，ADP induced PAgT，DD were independent risk factors for recurrent abortion patients with abortion≥3 times [odds ratios（OR）were 2.984，2.913 and 2.850，95% confidence intervals（CI） were 1.572-5.614，1.551-5.617 and 1.464-5.550，P<0.05）. The levels of AA induced PAgT，ADP induced PAgT and DD in recurrent abortion group were higher than those in non-abortion group （P<0.05）. The optimal cut-off values of AA induced PAgT，ADP induced PAgT and DD level in predicting recurrent abortion were 87.42%，85.46% and 415.13 μg·L^-1， respectively. Conclusions Patients with recurrent abortion≥3 times have higher AA induced PAgT，ADP induced PAgT and DD level，and the combined determination of various indicators has certain predictive value for recurrent abortion after re-pregnancy in patients with recurrent abortion.

Key words: Platelet aggregation rate, D-dimer, Recurrent abortion, Abortion frequency

CLC Number:

R446.1

LI Yue, LI Li, YANG Chen. Analysis of changes in platelet aggregation rate and D-dimer level in recurrent abortion patients with different times[J]. Laboratory Medicine, 2025, 40(3): 294-298.

Figures/Tables 7

References 23

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组别	例数	年龄/岁	孕前体重指数/（kg·m^-2）	孕周/周	最终妊娠结局		Fib/ （g·L^-1）	TT/s	PT/s	APTT/s
组别	例数	年龄/岁	孕前体重指数/（kg·m^-2）	孕周/周	未流产/ [例（%）]	再次流产/[例（%）]	Fib/ （g·L^-1）	TT/s	PT/s	APTT/s
2次组	56	27.34±2.06	22.62±2.78	8.45±1.40	17（30.36）	39（69.64）	1.58±0.45	20.90±2.35	12.98±1.41	25.95±2.76
≥3次组	87	27.23±2.35	22.58±3.07	8.48±1.45	24（27.59）	63（72.41）	2.86±0.82	16.27±1.46	10.76±0.83	21.40±1.80
统计值		0.286	0.079	0.122	0.128		10.683	14.541	11.850	11.940
P值		0.775	0.937	0.903	0.721		<0.001	<0.001	<0.001	<0.001

组别	例数	年龄/岁	孕前体重指数/（kg·m^-2）	孕周/周	最终妊娠结局		Fib/ （g·L^-1）	TT/s	PT/s	APTT/s
组别	例数	年龄/岁	孕前体重指数/（kg·m^-2）	孕周/周	未流产/ [例（%）]	再次流产/[例（%）]	Fib/ （g·L^-1）	TT/s	PT/s	APTT/s
2次组	56	27.34±2.06	22.62±2.78	8.45±1.40	17（30.36）	39（69.64）	1.58±0.45	20.90±2.35	12.98±1.41	25.95±2.76
≥3次组	87	27.23±2.35	22.58±3.07	8.48±1.45	24（27.59）	63（72.41）	2.86±0.82	16.27±1.46	10.76±0.83	21.40±1.80
统计值		0.286	0.079	0.122	0.128		10.683	14.541	11.850	11.940
P值		0.775	0.937	0.903	0.721		<0.001	<0.001	<0.001	<0.001

组别	例数	AA诱导PAgT/%	ADP诱导PAgT/%	DD/ （μg·L^-1）
2次组	56	81.26±7.42	80.75±6.24	395.57±54.22
≥3次组	87	92.54±5.13	93.45±4.97	492.74±85.63
t值		10.748	13.477	7.566
P值		<0.001	<0.001	<0.001

组别	例数	AA诱导PAgT/%	ADP诱导PAgT/%	DD/ （μg·L^-1）
2次组	56	81.26±7.42	80.75±6.24	395.57±54.22
≥3次组	87	92.54±5.13	93.45±4.97	492.74±85.63
t值		10.748	13.477	7.566
P值		<0.001	<0.001	<0.001

指标	AA诱导PAgT		ADP诱导PAgT		DD
指标	r值	P值	r值	P值	r值	P值
Fib	0.509	<0.001	0.516	<0.001	0.502	<0.001
TT	-0.510	<0.001	-0.519	<0.001	-0.515	<0.001
PT	-0.492	<0.001	-0.492	<0.001	-0.487	<0.001
APTT	-0.487	<0.001	-0.507	<0.001	-0.496	<0.001