Clinical application of plasma Omentin-1 determination in type 2 diabetes mellitus patients with lower limb vascular disease

doi:10.3969/j.issn.1673-8640.2014.07.006

Abstract

Abstract:

Objective　To investigate the changes of plasma Omentin-1 in type 2 diabetes mellitus（T2DM） patients with lower limb vascular disease（LLVD） and the relationship between Omentin-1 and high-sensitivity C-reactive protein（hs-CRP）. MethodsA total of 93 patients with T2DM were enrolled and classified into T2DM patients accompanied with LLVD（51cases， T2DM+LLVD group） and simple T2DM patients（42 cases， SDM group）， according to ankle brachial index ABI）， and 40 healthy subjects were enrolled as healthy controls（NC group）. Fasting plasma Omentin-1 levels were determined by enzyme-linked immunosorbent assay（ELISA）. The relationships between plasma Omentin-1 levels， hs-CRP and other metabolic parameters were also analyzed. ResultsPlasma Omentin-1 levels were significantly higher in SDM group [（18.30±5.17）ng/mL] and T2DM+LLVD group[（12.93±4.60）ng/mL] than that in NC group[（23.94±7.08）ng/mL]（P＜0.01）. Plasma Omentin-1 levels were significantly higher in T2DM+LLVD group than that in SDM group（P＜0.01）.Plasma Omentin-1 levels in T2DM+LLVD group were negatively related to hs-CRP， systolic blood pressure（SBP）， triglyceride（TG）， fasting blood glucose（FBG）， the index of homeostasis model of insulin resistance（HOMA-IR）and carotid intima-media thickness（CIMT）（r＝－0.405，－0.260，－0.148，－0.209，－0.307 and －0.419，P＝0.000，0.046，0.039，0.005，0.012 and 0.003）， and were correlated positively with ABI（r＝0.358，P＝0.007）. The hs-CRP， CIMT and ABI were the independent risk factors of plasma Omentin-1 in T2DM+LLVD group. ConclusionsPlasma Omentin-1 levels may be closely correlated with T2DM LLVD and atherosclerosis.

Key words: Omentin-1, Type 2 diabetes mellitus, Lower limb vascular disease, High-sensitivity C-reactive protein, Atherosclerosis

CLC Number:

R446.1

SUN Qingyan,LI Bingyun.. Clinical application of plasma Omentin-1 determination in type 2 diabetes mellitus patients with lower limb vascular disease[J]. , 2014, 29(7): 718-722.

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