Abstract:

Objective To investigate the clinical roles of interleukin（IL）-1,IL-2,IL-6,IL-8,IL-10 and high-sensitivity C-reactive protein（hs-CRP） levels in primary angle-closure glaucoma（PACG）. Methods A total of 72 patients with PACG and 55 healthy subjects were enolled. General information and eye parameters [intraocular pressure,central corneal thickness（CCT）,vertical cup-disc ratio（VCDR）,axial length（AL）,anterior chamber depth（ACD）,visual field mean deviation（MD） and visual field mean sensitivity（MS）] were collected and recorded in detail. Binary Logistic regression analysis was used to assess the risk factors of PACG. Spearman correlation analysis was used to assess the relationship between IL and eye parameters. Results The levels of IL-6,IL-8 and hs-CRP in PACG group were higher than those in control group（P<0.05）. There was no statistical significance in IL-1,IL-2 and IL-10 between PACG and control groups（P>0.05）. There was a positive correlation of IL-6 level with MD and VCDR in PACG patients（r=0.431 and 0.270,P<0.05）. There was a negative correlation between CCT and IL-8（r=-0.279,P=0.023）,and there were positive correlations of IL-8 with MD and VCDR（r=0.322 and 0.330,P<0.05）. Multivariate binary Logistic regression analysis showed that IL-6 [odds ratio（OR）=1.296,95% confidence interval（CI）1.009-1.664] and IL-8（OR=1.106,95% CI 1.044-1.172） were correlated with PACG. Conclusions IL-6,IL-8 and hs-CRP may be related to PACG.

Key words: Interleukin, High-sensitivity C-reactive protein, Primary angle-closure glaucoma