Establishment and application of miRNA sponges

doi:10.3969/j.issn.1673-8640.2014.02.021

Abstract

Abstract: MicroRNA(miRNA) is a kind of non-coding small RNA which participates in post-transcriptional expression modulation and involves in various kinds of physiological and pathologicalprocesses. miRNA sponges can sequester specific miRNA. miRNA sponges can bind to specific sites in the 3′untranslated region (UTR) of mRNA to sequester miRNA. Compared with antisense oligonucleotide inhibitors and genetic knockouts, miRNA sponges are valuable tools for miRNA loss-of-function studies in vitro and in vivo.With more and more non-coding RNAs were discovered, miRNA sponge has a indispensable role in the research of its function. This research will discuss the establishment and application of miRNA sponges.

Key words: MicroRNA, Sponge, Gene expression modulation

CLC Number:

Q503

LI Feng, LI Zhi. Establishment and application of miRNA sponges[J]. , 2014, 29(2): 178-181.

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