Abstract:

Objective To investigate the aspirin resistance (AR) and its risk factors in patients with acute cerebral infarction. Methods A total of 330 patients with acute cerebral infarction were enrolled. According to the platelet inhibition rate of arachidonic acid (AA) by thrombelastography, the patients were classified into AR group (platelet inhibition rate ≤20%), aspirin semi-resistance (ASR) group (platelet inhibition rate 20%-50%) and aspirin sensitivity (AS) group (platelet inhibition rate >50%). The incidence rate of AR was analyzed, the difference of clinical characteristics was analyzed, and Logistic regression analysis was performed for the risk factors of AR and ASR. Results The 33.9% patients had AR, and 19.7% patients had ASR. The high sensitive C reactive protein (hsCRP) level in AR+ASR group increased obviously compared with that in AS group(P<0.05).In the patients older than 65 years old,the incidence rate of AR+ASR in high risk patients increased significantly (P<0.05). Logistic regression analysis showed that platelet counts [odd ratio (OR)=0.996,95％ confidence interval (CI): 0.991-0.999,P=0.041] and hs-CRP levels(OR=0.972,95％CI: 0.959-0.996,P=0.014) were risk factors for AR and ASR. Conclusions The incidence rate of AR in patients with acute cerebral infarction may be related to platelet count and inflammation.

Key words: Cerebral infarction, Aspirin resistance, Thrombelastography