Abstract:

Objective To study the application significance of homocysteine (Hcy) and C reactive protein(CRP) in acute cerebral vascular diseases (CVD), like intracerebral hemorrhage(ICH) and cerebral infarction(CI). Methods There were ICH group (68 cases) and CI group (69 cases). A total of 117 healthy subjects were enrolled as healthy control group. Hcy was determined by cycle enzyme, CRP levels were measured by immuno-enhanced turbidimetry, and the means of Hcy and CRP were compared. The receiver operating characteristic (ROC) curve was drawn, and the relation between CRP and acute CVD and the clinical application significance were analyzed. Results The levels of Hcy in CI group [15.1(13.1-19.0)μmol/L] and ICH group [13.3(11.2-16.3)μmol/L] were higher than that in healthy control group [11.0(9.1-12.9)μmol/L, P<0.01]. The levels of CRP in CI group [10.5(4.5-41.4)mg/L] and ICH group [30.2(12.3-72.2) mg/L] were higher than that in healthy control group [0.1(0.1-0.1)mg/L, P<0.01]. Hcy and CRP abnormal rates in CI and ICH groups had significant difference compared with healthy control group (P<0.01), and Hcy abnormal rates between CI and ICH groups had difference (P<0.05). For acute CVD, the areas under ROC curve of Hcy and CRP were 0.762 and 0.967, and there was significance in the diagnosis of acute CVD (P=0.000). It could improve the possibility in the diagnosis of acute CVD. Conclusions Serum Hcy and CRP levels increase significantly in patients with CVD compared with healthy subjects, and Hcy and CVD exist independent correlation. CRP as an overall quantitative index to evaluate body injury has a certain significance in the diagnosis of acute CVD.

Key words: Homocysteine, C reactive protein, Acute cerebral vascular disease, Cerebral infarction, Intracerebral hemorrhage, Receiver operating characteristic curve