Clinical application of homocysteine and vascular endothelial function determinations in cerebral infarction

doi:10.3969/j.issn.1673-8640.2014.10.010

Abstract

Abstract: Objective To observe serum homocysteine (Hcy) and vascular endothelial function parameters such as endothelin-1(ET-1), nitric oxide(NO)and vascular endothelial growth factor(VEGF) in cerebral infarction patients, and to investigate the relationship with cerebral infarction and the clinical application significance. Methods The levels of serum Hcy, NO, ET-1 and VEGF were determined in 90 patients with cerebral infarction (cerebral infarction group) and 80 healthy subjects (healthy control group). The abnormal determination rate was calculated, and the results were analyzed comparatively. Resutls The levels of serum Hcy, ET-1 and VEGF increased significantly in cerebral infarction group compared with those in healthy control group(P<0.05), but NO level decreased significantly (P<0.05). The abnormal determination rates of serum Hcy, NO, ET-1 and VEGF in cerebral infarction group were higher than those in healthy control group (P<0.05). Conclusions Hcy and vascular endothelial function parameters are related to cerebral infarction.

Key words: Homocysteine, Nitric oxide, Endothelin-1, Vascular endothelial growth factor, Cerebral infarction

CLC Number:

R446.1

LI Yuanyuan, WANG Qi.. Clinical application of homocysteine and vascular endothelial function determinations in cerebral infarction[J]. , 2014, 29(10): 1028-1030.

References

[1] 陈峻,张惜,陈翠英,等.急性脑梗死患者联合检测hs-CRP、Hcy及血小板的应用价值[J].血栓与止血学,2013,19(1):17-18.
[2] 各类脑血管病诊断要点[J].中华神经科杂志,1996,42(6): 60-61.
[3] 江丽霞,钟星明,施少华,等.同型半胱氨酸和脂蛋白(a)联合检测与冠心病的相关性研究[J].检验医学,2012,27(11):924.
[4] 司家峰.青年短暂性脑缺血发作与血清同型半胱氨酸的关系[J].检验医学,2010,25(11): 874.
[5] 彭乃杰,李克诚,夏菲,等.血清同型半胱氨酸水平与急性脑梗死的相关性研究[J].检验医学,2013,28(3):257-258.
[6] 瞿国英,林炜炜,戴越刚.同型半胱氨酸水平与脑梗死患者传统危险因素的相关性分析[J].检验医学,2013,28(2):102-105.
[7] 刘晓峰,陈雪礼,涂艳.血浆同型半胱氨酸与B型钠尿肽联合检验在急性心肌梗死中的应用评价[J].检验医学,2013,28(5):379-381.
[8] 吴仕君,王胜梅.冠心病患者血清Hcy和Cys C水平的变化[J].检验医学,2014,29(4):327.
[9] 姜宇海,王亚平.冠心病患者同型半胱氨酸的变化及其临床价值[J].检验医学,2014,29(5):576-577.
[10] Cuba SC,Fink LM, Fonseca V. Hyperhomocysteinemia. An emerging and important risk factor for thromemblic and cardiovascular disease[J].Am J Clin Pathol,1996,106(6): 709-722.
[11] 王中魁,王卫,魏东宁.高同型半胱氨酸血症与脑梗塞TOAST亚型关系及治疗研究[J].中国医药导刊,2010,12(5):758-759.
[12] Narayan SK,Firbank MJ,Saxby BK,et al. Elevated plasma homocysteine is associated with increased brain atrophy rates in older subjects with mild hypertension[J].Dement Ceriatr Cogn Disord,2011,31(5):341-348.
[13] 吴海琴,张欣,汤燕,等.幽门螺杆菌感染与脑梗死患者同型半胱氨酸的关系[J].浙江大学学报(医学版),2012,41(1):89-92.
[14] 陈洪汉.脑梗死危险因素与血管内皮功能[J].医学综述,2011,17(20):3054-3056.
[15] 陈景红,高俊淑,李娜,等.老年急性脑梗死患者VEGF和GFAP水平的动态变化[J].中国老年学杂志,2011,31(4):687-688.