Abstract: Objective To evaluate the clinical application significance of the combined determination of serum amyloid A (SAA) and C-reactive protein (CRP). Methods The levels of serum SAA and CRP in 82 inflammatory disease patients (15 cases of pneumonia, 23 cases of acute bronchitis, 17 cases of acute appendicitis, 16 cases of acute cholecystitis and 11 cases of pancreatitis) and 92 healthy controls were determined by colloidal gold method and immunoturbidimetry, respectively. Their concentration median and positive determination rate were analyzed comparatively between the 2 groups. Resutls The serum SAA and CRP medians in inflammatory disease group were 149.50 mg/L and 34.20 mg/L, respectively, which were obviously higher than those in healthy control group (4.60 mg/L and 3.82 mg/L). There was a statistical significance between the 2 groups (P<0.05). The positive determination rates of serum SAA and CRP in inflammatory disease group were 87.80% and 79.26%, respectively. Conclusions SAA has the same trend with CRP when inflammatory disease happens, and shows a more sensitive performance than CRP. SAA and CRP can be used as meaningful markers for monitoring inflammation. The combined determination of SAA and CRP could improve the determination rate of inflammatory disease, which provides a more sensitive reference for diagnosis.

Key words: Amyloid A, C-reactive protein, Inflammatory disease group, Combined determination