Abstract:

Objective To evaluate the role of new neutrophil parameters（NEU-X，NEU-Y and NEU-Z）in the auxiliary diagnosis of sepsis. Methods Totally，55 sepsis inpatients，73 non-sepsis inpatients and 175 healthy subjects from the North Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January to December 2021 were enrolled. C-reactive protein （CRP），white blood cell （WBC） count，the absolute value of neutrophils （NEUT#）NEUT count and NEU-X，NEU-Y and NEU-Z were compared among the 3 groups. The correlation between NEU-X，NEU-Y，NEU-Z and procalcitonin （PCT） in sepsis group was analyzed by Pearson analysis. Sepsis group was sub-classified into Gram-negat=ive bacterium infection group，Gram-positive bacterium infection group and fungal infection group，and the differences of NEU-X，NEU-Y and NEU-Z among the 3 groups were compared. Receiver operating characteristic （ROC） curve was used to evaluate the efficacy of NEU-X，NEU-Y and NEU-Z in diagnosing sepsis. Results NEU-X and NEU-Y in sepsis group were higher than those in healthy control group and non-sepsis group（P<0.001），CRP，WBC count and NEUT# were higher than those in healthy control group（P<0.001），but there was no statistical significance between them and non-sepsis group （P>0.05）. NEU-X，NEU-Y and NEU-Z were positively correlated with PCT（r values were 0.392 5，0.532 3，0.416 0，P<0.01）. NEU-Y in fungal infection group was lower than that in Gram-negative bacteria infection group（P<0.05）. The area under curve of NEU-Y for the diagnosis of sepsis was 0.681 8 [95% confidence interval （CI） 0.588 9-0.778 4]. The area under curve of NEU-Y was 0.810 3 （95%CI 0.731 0-0.889 7）. Conclusions NEU-X and NEU-Y can be used in the auxiliary diagnosis of sepsis.

Key words: Neutrophil, New parameter, Sepsis, C-reactive protein, Diagnosis