Abstract:

Objective To investigate the correlation of serum homocysteine(Hcy) and Helicobacter pylori (Hp) infection with acute cerebral infarction (ACI) patients. Methods Serum Hcy (enzymatic cycling method), high-sensitivity C reactive protein (hs-CRP) and blood lipid levels of 120 ACI patients and 70 healthy subjects were detected. Serum Hp IgG antibody (colloidal gold), rapid urease test (RUT) and ¹⁴C urea breath test (¹⁴C-UBT) were also detected and performed. Results The Hp infection rate of ACI group (71.7%) was significantly higher than that of control group (44.3%, χ²= 14.009, P<0.05).Serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), Hcy and hs-CRP levels [(6.28±0.93) mmol/L, (3.09±0.86) mmol/L, (3.83±0.97) mmol/L,(28.8±6.4) μmol/L and (7.97±2.13) mg/L] in Hp infection group were significantly higher than those in Hp non-infection group [(5.19±0.85) mmol/L,(2.27±0.74) mmol/L,(2.78±0.92) mmol/L, (19.7±5.4)μmol/L and (3.45±1.07)mg/L, t=5.601, 3.235, 4.336, 4.261 and 3.318, P<0.05]. However, serum high-density lipoprotein cholesterol (HDL-C) level [(1.07±0.34) mmol/L] was significantly lower than that in Hp non-infection group [(1.82±0.41) mmol/L, t=3.725, P<0.05]. Hcy level in ACI group was significantly correlated with Hp infection (r=0.321, P<0.05). Conclusions The Hcy levels in ACI patients are correlated with Hp infection, and the levels of serum Hcy and Hp infection results could hint the state of illness.

Key words: Homocysteine, Helicobacter pylori, Correlation, Acute cerebral infarction