微生物学在哮喘发生中的作用

doi:10.3969/j.issn.1673-8640.2013.10.020

摘要/Abstract

摘要：

哮喘是常见的慢性炎症性呼吸道疾病，患者气道呈高反应性，临床表现为反复发作的喘息、气急、胸闷或咳嗽，伴哮鸣音并以呼气为主的呼吸困难。这些临床表现是由许多不同程度的病理生理变化而形成的综合征。当患者个体首次接触过敏原抗原时，参与固有免疫的上皮细胞、树突状细胞、巨噬细胞、中性粒细胞等相继激活，识别并阻止抗原入侵。同时肥大细胞脱颗粒释放炎症因子并形成IgE介导的过敏反应。抗原识别的信号被抗原递呈细胞扩大传递，引起嗜酸性粒细胞和淋巴细胞的呼吸道募集，产生炎症反应，从而引起支气管痉挛、水肿、支气管平滑肌收缩等

中图分类号:

R446.5

赵敏，李智. 微生物学在哮喘发生中的作用[J]. 检验医学, 2013, 28(10): 944-947.

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