过敏性鼻炎-哮喘综合征患儿血清25（OH）D与病情控制的相关性

doi:10.3969/j.issn.1673-8640.2022.01.006

检验医学 ›› 2022, Vol. 37 ›› Issue (1): 32-35.DOI: 10.3969/j.issn.1673-8640.2022.01.006

过敏性鼻炎-哮喘综合征患儿血清25（OH）D与病情控制的相关性

李定富¹, 黄健¹, 蔡枚龄², 王丽珍², 简开乾¹, 杨飞飞³()

1.海南西部中心医院检验科,海南儋州 571700
2.海南西部中心医院儿科,海南儋州 571700
3.咸阳市中心医院检验科,陕西咸阳 712000

收稿日期:2021-01-18 修回日期:2021-07-12 出版日期:2022-01-30 发布日期:2022-03-07
通讯作者: 杨飞飞
作者简介:杨飞飞,E-mail： 1002117509@qq.com。
李定富,男,1988年生,学士,主管技师,主要从事临床生化检验工作。

Relationship between serum 25（OH）D and disease control in children with allergic rhinitis-asthma syndrome

LI Dingfu¹, HUANG Jian¹, CAI Meiling², WANG Lizhen², JIAN Kaigan¹, YANG Feifei³()

1. Department of Clinical Laboratory,Hainan Western Central Hospital,Danzhou 571700,Hainan,China
2. Department of Pediatrics,Hainan Western Central Hospital,Danzhou 571700,Hainan,China
3. Department of Clinical Laboratory,Xianyang Central Hospital,Xianyang 712000,Shaanxi,China

Received:2021-01-18 Revised:2021-07-12 Online:2022-01-30 Published:2022-03-07
Contact: YANG Feifei

摘要/Abstract

摘要：

目的探讨过敏性鼻炎-哮喘综合征患儿血清25-羟基维生素D[25（OH）D]水平与病情严重程度及激素反应性的相关性。方法选取过敏性鼻炎患儿、哮喘患儿、过敏性鼻炎-哮喘综合征患儿各50例,以体检健康儿童50名作为正常对照组。检测所有对象的血清25（OH）D水平,同时检测肺功能[用力肺活量（FVC）、一秒用力呼气容积（FEV1）、中期呼气流速（FEF25%~75%）、最大呼吸流量（PEF）]。采用改良英国医学研究会呼吸困难指数（mMRC）评分、过敏性鼻炎评分量表（SFAR）、哮喘控制测试（ACT）评估过敏性鼻炎-哮喘综合征患儿的病情控制情况。根据激素使用剂量将过敏性鼻炎-哮喘综合征患儿分为低剂量激素组、中剂量激素组、高剂量激素组。采用线性回归分析评估血清25（OH）D水平对患儿肺功能及病情控制情况的影响。结果哮喘组、过敏性鼻炎组、过敏性鼻炎-哮喘综合征组血清25（OH）D水平均低于正常对照组（P<0.01）,且哮喘组、过敏性鼻炎组、过敏性鼻炎-哮喘综合征组之间差异均有统计学意义（P<0.01）。低剂量激素组、中剂量激素组、高剂量激素组之间血清25（OH）D水平差异均有统计学意义（P<0.01）。线性回归分析结果显示,过敏性鼻炎-哮喘综合征患儿25（OH）D对FEV1、FVC、FEF25%~75%、PEF、ACT评分、mMRC评分、SFAR评分均有影响（P<0.01）。结论血清25（OH）D水平与过敏性鼻炎-哮喘综合征患儿肺功能及病情控制有关。

关键词: 25-羟基维生素D, 过敏性鼻炎-哮喘综合征, 儿童

Abstract:

Objective To investigate the relationship between serum 25-hydroxyvitamin D [25（OH）D] level and disease severity,hormone responsiveness in children with allergic rhinitis-asthma syndrome. Methods Totally,50 healthy subjects were enrolled as control group,and 150 patients were enrolled in allergic rhinitis group（50 cases）,asthma group（50 cases） and allergic rhinitis-asthma syndrome group（50 cases）. Lung function [forced vital capacity（FVC）,forced expiratory volume in one second（FEV1）,forced expiratory flow rate 25%-75%（FEF25%-75%） and peak expiratory flow（PEF）] and serum 25（OH）D were determined. The situation of disease control was evaluated by modified British medical research council（mMRC） score,score for allergic rhinitis（SFAR） and asthma control test（ACT） score. According to hormone usage doses,allergic rhinitis-asthma syndrome group was subclassified into low-dose hormone group,middle-dose hormone group and high-dose hormone group. Linear regression analysis was used to evaluate the influence of 25（OH）D level on lung function and disease control. Results The serum 25（OH）D levels of asthma group,allergic rhinitis group and allergic rhinitis-asthma syndrome group were lower than that in control group（P<0.01）,and the difference among asthma group,allergic rhinitis group and allergic rhinitis-asthma syndrome group had statistical significance（P<0.01）. There was statistical significance in serum 25（OH）D levels among low-dose hormone group,middle-dose hormone group and high-dose hormone group（P<0.01）. Linear regression analysis showed that 25（OH）D in children with allergic rhinitis-asthma syndrome influenced on FEV1,FVC,FEF25%-75%,PEF,ACT score,mMRC score and SFAR（P<0.01）. Conclusions Serum 25（OH）D level is related to lung function and disease control in children with allergic rhinitis-asthma syndrome.

Key words: 25-Hydroxyvitamin D, Allergic rhinitis-asthma syndrome, Children

中图分类号:

R446.1

李定富, 黄健, 蔡枚龄, 王丽珍, 简开乾, 杨飞飞. 过敏性鼻炎-哮喘综合征患儿血清25（OH）D与病情控制的相关性[J]. 检验医学, 2022, 37(1): 32-35.

LI Dingfu, HUANG Jian, CAI Meiling, WANG Lizhen, JIAN Kaigan, YANG Feifei. Relationship between serum 25（OH）D and disease control in children with allergic rhinitis-asthma syndrome[J]. Laboratory Medicine, 2022, 37(1): 32-35.

图/表 2

参考文献 21

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组别	例数	25（OH）D/（ng/mL）
正常对照组	50	22.79±3.08
哮喘组	50	21.15±2.98^*
过敏性鼻炎组	50	17.56±2.32^*#
过敏性鼻炎-哮喘综合征组	50	19.38±2.48^*#△
F值		34.10
P值		<0.01

组别	例数	25（OH）D/（ng/mL）
正常对照组	50	22.79±3.08
哮喘组	50	21.15±2.98^*
过敏性鼻炎组	50	17.56±2.32^*#
过敏性鼻炎-哮喘综合征组	50	19.38±2.48^*#△
F值		34.10
P值		<0.01

组别	例数	25（OH）D/（ng/mL）
低剂量激素组	49	20.63±2.22
中剂量激素组	52	19.52±2.16^*
高剂量激素组	45	18.33±2.35^*#
F值		12.37
P值		<0.01

组别	例数	25（OH）D/（ng/mL）
低剂量激素组	49	20.63±2.22
中剂量激素组	52	19.52±2.16^*
高剂量激素组	45	18.33±2.35^*#
F值		12.37
P值		<0.01

过敏性鼻炎-哮喘综合征患儿血清25（OH）D与病情控制的相关性

Relationship between serum 25（OH）D and disease control in children with allergic rhinitis-asthma syndrome

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