肠道微生物群在妊娠期肥胖及糖尿病中的作用

doi:10.3969/j.issn.1673-8640.2019.03.020

摘要/Abstract

摘要：

肠道微生物群是定植在人体肠道内的全部微生物及其基因的统称。近年来研究发现,肠道微生物群的改变与妊娠期肥胖及糖尿病的发生、发展密切相关。肠道微生物群的改变可能通过影响某些代谢机制影响相关疾病的发生、发展,其具体的分子生物学机制尚不明确。文章对肠道微生物群在妊娠期肥胖及糖尿病中的作用进行综述。

关键词: 肠道微生物群, 妊娠期肥胖, 妊娠期糖尿病

Abstract:

Gut microbiota is a general term for all microorganisms and their genes that are colonized in human intestine. In recent years,studies have found that the changes in gut microbiota are related to the development of gestational obesity and diabetes mellitus. The changes in gut microbiota may affect the occurrence and development of related diseases by affecting certain metabolic mechanisms. However,the specific molecular biological mechanisms have not been thoroughly studied. Therefore,this review focuses on the role of gut microbiota in gestational obesity and diabetes mellitus.

Key words: Gut microbiota, Gestational obesity, Gestational diabetes mellitus

中图分类号:

R446.1

张凯楠, 张朝霞. 肠道微生物群在妊娠期肥胖及糖尿病中的作用[J]. 检验医学, 2019, 34(3): 276-279.

ZHANG Kainan, ZHANG Zhaoxia. Role of gut microbiota in gestational obesity and diabetes mellitus[J]. Laboratory Medicine, 2019, 34(3): 276-279.

图/表 1

参考文献 37

[1]	ANNA V, VAN DER PLOEG H P,CHEUNG N W,et al. Sociodemographic correlates of the increasing trend in prevalence of gestational diabetes mellitus in a large population of women between 1995 and 2005[J]. Diabetes Care,2008,31(12):2288-2293.
[2]	NCD Risk Factor Collaboration(NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants[J]. Lancet,2016,387(10026):1377-96.
[3]	DESISTO C L, KIM S Y, SHARMA A J.Prevalence estimates of gestational diabetes mellitus in the United States,Pregnancy Risk Assessment Monitoring System (PRAMS), 2007-2010[J]. Prev Chronic Dis,2014,11:E104.
[4]	FERRARA A.Increasing prevalence of gestational diabetes mellitus: a public health perspective[J]. Diabetes Care, 2007,30(Suppl 2):S141-S146.
[5]	IGNELL C, CLAESSON R, ANDERBERG E, et al.Trends in the prevalence of gestational diabetes mellitus in southern Sweden, 2003-2012[J]. Acta Obstet Gynecol Scand, 2014,93(4):420-424.
[6]	ZHU Y, ZHANG C.Prevalence of gestational diabetes and risk of progression to type 2 diabetes: a global perspective[J]. Curr Diab Rep, 2016,16(1):7.
[7]	PAGE K A, ROMERO A, BUCHANAN T A, et al.Gestational diabetes mellitus, maternal obesity, and adiposity in offspring[J]. J Pediatr, 2014,164(4):807-810.
[8]	BONEY CM, VERMA A, TUCKER R, et al.Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus[J]. Pediatrics, 2005,115(3):e290-e296.
[9]	PATEL S, LAWLOR D A, CALLAWAY M,et al.Association of maternal diabetes/glycosuria and pre-pregnancy body mass index with offspring indicators of non-alcoholic fatty liver disease[J]. BMC Pediatr, 2016,16:47.
[10]	SEARS C, HIVERT M F.Examination of pathways linking maternal glycemia during pregnancy and increased risk for type 2 diabetes in offspring[J]. Can J Diabetes, 2015,39(6):443-444.
[11]	XIANG A H, WANG X, MARTINEZ M P, et al.Association of maternal diabetes with autism in offspring[J]. JAMA, 2015,313(14):1425-1434.
[12]	RAUTAVA S,LUOTO R,SALMINEN S,et al.Microbial contact during pregnancy, intestinal colonization and human disease[J]. Nat Rev Gastroenterol Hepatol, 2012,9(10):565-576.
[13]	Human Microbiome Project Consortium. Structure,function and diversity of the healthy human microbiome[J]. Nature,2012,486(7402):207-214.
[14]	QIN J, LI R, RAES J, et al.A human gut microbial gene catalogue established by metagenomic sequencing[J]. Nature,2010,464(7285):59-65.
[15]	BÄCKHED F, DING H, WANG T, et al. The gut microbiota as an environmental factor that regulates fat storage[J]. Proc Natl Acad Sci U S A,2004,101(44):15718-15723.
[16]	LEY R E,BÄCKHED F, TURNBAUGH P,et al. Obesity alters gut microbial ecology[J]. Proc Natl Acad Sci U S A,2005,102(31):11070-11075.
[17]	GIRDWOOD R H.The possible effects of gastro-intestinal bacteria on the absorption of vitamin B12[J]. Rev Hematol,1955,10(2):187-193.
[18]	EVERARD A, CANI P D.Gut microbiota and GLP-1[J]. Rev Endocr Metab Disord,2014,15(3):189-196.
[19]	PLÖGER S, STUMPFF F, PENNER G B, et al. Microbial butyrate and its role for barrier function in the gastrointestinal tract[J]. Ann N Y Acad Sci,2012,1258:52-59.
[20]	KAU A L, AHERN P P, GRIFFIN N W, et al.Human nutrition, the gut microbiome and the immune system[J]. Nature,2011,474(7351):327-336.
[21]	KOREN O,GOODRICH J K,CULLENDER T C,et al.Host remodeling of the gut microbiome and metabolic changes during pregnancy[J]. Cell, 2012,150(3):470-480.
[22]	COLLADO M C, ISOLAURI E, LAITINEN K,et al.Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women[J]. Am J Clin Nutr, 2008,88(4):894-899.
[23]	FUGMANN M, BREIER M, ROTTENKOLBER M, et al.The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes[J]. Sci Rep, 2015,5:13212.
[24]	LARSEN N, VOGENSEN F K, VAN DEN BERG F W, et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults[J]. PLoS One, 2010,5(2):e9085.
[25]	KARLSSON F H, TREMAROLI V, NOOKAEW I, et al.Gut metagenome in European women with normal, impaired and diabetic glucose control[J]. Nature, 2013,498(7452):99-103.
[26]	QIN J, LI Y, CAI Z, et al.A metagenome-wide association study of gut microbiota in type 2 diabetes[J]. Nature, 2012,490(7418):55-60.
[27]	GOMEZ-ARANGO L F, BARRETT H L, MCINTYRE H D, Cet al. Connections between the gut microbiomeC Connections between the gut microbiome and metabolic hormones in early pregnancy in overweight and obese women[J]. Diabetes, 2016,65(8):2214-2223.
[28]	COLLADO M C, ISOLAURI E, LAITINEN K, et al.Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women[J]. Am J Clin Nutr, 2008,88(4):894-899.
[29]	SANTACRUZ A, COLLADO M C, GARCÍA-VALDÉS L, et al. Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women[J]. Br J Nutr, 2010,104(1):83-92.
[30]	MACDONALD P E, EL-KHOLY W, RIEDEL M J, et al.The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion[J]. Diabetes, 2002,51(Suppl 3):S434-S442.
[31]	LIN H V, FRASSETTO A, KOWALIK E J, et al.Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms[J]. PLoS One, 2012,7(4):e35240.
[32]	CANI P D, AMAR J, IGLESIAS M A, et al.Metabolic endotoxemia initiates obesity and insulin resistance[J]. Diabetes, 2007,56(7):1761-1772.
[33]	FASANO A.Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer[J]. Physiol Rev, 2011,91(1):151-175.
[34]	JAYASHREE B, BIBIN Y S, PRABHU D, et al.Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes[J]. Mol Cell Biochem, 2014,388(1-2):203-210.
[35]	FORSLUND K, HILDEBRAND F, NIELSEN T, et al.Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota[J]. Nature, 2015,528(7581):262-266.
[36]	DE LA CUESTA-ZULUAGA J, MUELLER N T, CORRALES-AGUDELO V, et al. Metformin is associated with higher relative abundance of mucin-degrading akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut[J]. Diabetes Care, 2017,40(1):54-62.
[37]	ZHOU Z Y, REN L W, ZHAN P, et al.Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling[J]. Acta Pharmacol Sin, 2016,37(8):1063-1075.