关键词: 糖化血红蛋白, 糖化白蛋白, 妊娠期糖尿病, 初筛

Abstract:

Objective 　To investigate the significance of glycated albumin（GA） and glycosylated hemoglobin A_1c（HbA_1c） in screening gestational diabetes mellitus（GDM）. Methods　There were 289 women with pregnancy for 22-28 weeks. A total of 202 cases were enrolled in normal blood glucose group， and 87 cases were enrolled in GDM group. Hexokinase method was used to detect glucose， and high pressure liquid chromatography was used to detect HbA_1c，and enzyme method was used to detect GA. Results　HbA_1c of GDM group was 5.20%±0.09%， which was significantly higher than that of normal blood glucose group（5.03%±0.02%，P＜0.01）. GA of GDM group was 13.48%±0.28%， that of normal blood glucose group was 13.39%±0.09%， and the difference had no statistical significance（P＞0.05）. Pearson correlation analysis showed that glucose was positively correlated with HbA_1c（r=0.203，P＜0.01）， and there was no correlation between glucose and GA（r=0.114，P＞0.05）. There was no correlation between HbA_1c and GA（r=0.041，P＞0.05）. Using HbA_1c 95% value（5.50%） in normal blood glucose group as the judgment basis for screening GDM， the specificity was 94.55%， and the sensitivity was 86.21%. Conclusions　HbA_1c， other than GA， is a good indicator for screening GDM initially.

Key words: Glycosylated hemoglobin A1c, Glycated albumin, Gestational diabetes mellitus, Initial screening