糖化血红蛋白及糖化白蛋白在妊娠期糖尿病诊断中的价值

doi:10.3969/j.issn.1673-8640.2014.02.011

检验医学 ›› 2014, Vol. 29 ›› Issue (2): 135-138.DOI: 10.3969/j.issn.1673-8640.2014.02.011

糖化血红蛋白及糖化白蛋白在妊娠期糖尿病诊断中的价值

程晨¹, 张越², 何奖图², 肖伟凡², 高艳², 李静², 潘秋辉²

1. 同济大学附属第十人民医院检验科, 上海 200072;
2. 同济大学附属第十人民医院中心实验血清室, 上海 200072

收稿日期:2013-09-27 出版日期:2014-02-20 发布日期:2014-02-20
通讯作者: 潘秋辉, 联系电话:021-66303403
作者简介:程晨, 女, 1988年生, 学士, 主要从事临床常见病的实验诊断工作。

Significance of glycosylated hemoglobin A_1c and glycated albumin for the diagnosis of gestational diabetes mellitus

CHENG Chen¹, ZHANG Yue², HE Jiangtu², XIAO Weifan², GAO Yan², LI Jing², PAN Qiuhui²

1. Department of Clinical Laboratory, Tenth People′s Hospital of Tongji University, Shanghai 200072, China; 2. Central Laboratory, Tenth People′s Hospital of Tongji University, Shanghai 200072, China

Received:2013-09-27 Online:2014-02-20 Published:2014-02-20

摘要/Abstract

摘要：

目的评估糖化血红蛋白(HbA_1c)和血清糖化白蛋白(GA)在妊娠期糖尿病(GDM)患者早期监测中的作用。方法根据美国糖尿病协会(ADA)建议, 以口服75 g葡萄糖耐量试验(OGTT)测定值作为诊断GDM的标准, 将98例妊娠妇女(孕期22～24周)分为正常妊娠组50例、GDM组48例, 同时测定2组的HbA_1c和GA, 并进行统计学分析及受试者工作特征(ROC)曲线分析。结果 GDM组的HbA_1c和GA明显高于正常妊娠组(P<0.01)。当HbA_1c的Cut-off值为5.15%时, ROC曲线下面积为0.954±0.020, 敏感性为87.5%, 特异性为92.0%。当GA的Cut-off值12.50%时, ROC曲线下面积为0.910±0.029, 敏感性为81.3%, 特异性为84.0%。HbA_1c和GA联合诊断GDM的敏感性为70.8%、特异性为98.0%。结论当HbA_1c＞5.15%和GA＞12.50% 时, 诊断GDM的敏感度和特异性较高。HbA_1c和GA联合检测对GDM有重要价值。

关键词: 糖化血红蛋白, 糖化白蛋白, 妊娠期糖尿病

Abstract:

Objective To evaluate the utilities of glycosylated hemoglobin A_1c(HbA_1c) and serum glycated albumin(GA) for the early monitoring of gestational diabetes mellitus(GDM). Methods A total of 98 pregnant women with their estimated gestational age between 22 and 24 weeks were enrolled for GDM diagnosis using 75 g oral glucose tolerance test (OGTT) based on American Diabetes Association(ADA) criteria, and were classified into normal pregnancy group (50 cases) and GDM group (48 cases). HbA_1c and GA were also determined simultaneously, and the results were analyzed statistically and byreceiver operating characteristic (ROC) curve. Results The HbA_1c and GA levels in GDM group were significantly higher than those in normal pregnancy group(P<0.01). The area under ROC curve of HbA_1c was 0.954±0.020 at the cut-off value of 5.15% with sensitivity of 87.5% and specificity of 92.0%. The area under ROC curve of GA was 0.910±0.029 at the cut-off value of 12.50% with sensitivity of 81.3% and specificity of 84.0%. The sensitivity was 70.8%, and the specificity was 98.0% in diagnosing GDM by the combined determination of HbA_1c and GA. Conclusions When HbA_1c>5.15% and GA>12.50%, there are high sensitivity and specificity for the diagnosis of GDM.The combined determination of HbA_1c and GA has the significance for the diagnosis of GDM.

Key words: Glycosylated hemoglobin A_1c, Glycated albumin, Gestational diabetes mellitus

中图分类号:

R446.1

程晨, 张越, 何奖图, 肖伟凡, 高艳, 李静, 潘秋辉. 糖化血红蛋白及糖化白蛋白在妊娠期糖尿病诊断中的价值[J]. 检验医学, 2014, 29(2): 135-138.

CHENG Chen, ZHANG Yue, HE Jiangtu, XIAO Weifan, GAO Yan, LI Jing, PAN Qiuhui. Significance of glycosylated hemoglobin A_1c and glycated albumin for the diagnosis of gestational diabetes mellitus[J]. , 2014, 29(2): 135-138.

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糖化血红蛋白及糖化白蛋白在妊娠期糖尿病诊断中的价值

Significance of glycosylated hemoglobin A_1c and glycated albumin for the diagnosis of gestational diabetes mellitus

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糖化血红蛋白及糖化白蛋白在妊娠期糖尿病诊断中的价值

Significance of glycosylated hemoglobin A1c and glycated albumin for the diagnosis of gestational diabetes mellitus

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