Objective To investigate the clinical role of serum matrix metalloprotein（MMP）-2 and typeⅠcollagen carboxyl terminal peptide（ICTP） in acute myocardial infarction（AMI）. Methods Totally,120 patients with AMI were enrolled,and they were classified into mild group（Gensini score 0-7,36 cases）,moderate group（Gensini score 8-14,54 cases）,severe group（Gensini score 14,30 cases）,and 120 healthy subjects were enrolled as healthy control group. The general data and laboratory determination results,including sex,age,body mass index（BMI）,smoking history,mean arterial pressure（MAP）,low-density lipoprotein cholesterol（LDL-C）,triglyceride（TG）,etc.,were collected. The hypertension history,diabetes mellitus history,Gensini score and cardiac troponin T（cTnT） results of AMI patients were collected. The serum levels of ICTP and MMP-2 were determined. Results There was no statistical significance in the general data（sex,age,BMI,MAP,LDL-C,TG and smoking history） between healthy control group and AMI group（P>0.05）. The levels of serum ICTP and MMP-2 in AMI group were higher than those in healthy control group（P<0.001）. The results of ROC curve analysis showed that the areas under curves（AUC） of ICTP and MMP-2 were 0.862 and 0.887,the optimal cut-off values were 6.4 and 3.6 ng/mL,the sensitivities were 81.67% and 85.00%,the specificities were 83.33% and 83.33%,respectively. The AUC of ICTP combined with MMP-2 was 0.978,the sensitivity was 96.67%,and the specificity was 95.00%. The Gensini score and serum cTnT,ICTP,MMP-2 levels of mild stenosis group,moderate stenosis group and severe stenosis group were increased in turn,and there was statistical significance among the 3 groups（P<0.05）,but there was no statistical significance in the other indexes between the 2 groups（P>0.05）. Pearson correlation analysis showed that serum ICTP and MMP-2 were positively correlated with Gensini score（r=0.862 and 0.858,P<0.001）. Conclusions Serum ICTP and MMP-2 play roles in AMI,which can be used for AMI diagnosis and condition evaluation.
