Abstract:

Objective To investigate the correlations of coagulation function,serum C-reactive protein（CRP）and Tau protein in patients with brain injury with the severity and prognosis of brain injury. Methods Totally,103 patients with brain injury were enrolled,which were classified into heavy group（30 cases）,medium group（39 cases） and light group（34 cases）. According to Glasgow Coma Scale（GCS）scores,they were classified into good prognosis group（68 cases） and poor prognosis group（35 cases）. Prothrombin time（PT）,activated partial thrombin time（APTT）,thrombin time （TT）,fibrinogen（Fib）,D-dimer（DD）,CRP and Tau protein levels were determined. Results There were statistical significance for coagulation function,serum CRP and Tau protein in different degrees of brain injury before treatment（P<0.05）. As the degree of brain injury increasing,the levels of PT,APTT,TT,DD,CRP and Tau protein were increased,and the level of Fib was decreased（P<0.05）. Before and after treatment,the levels of PT,APTT,TT,DD,CRP and Tau protein in good prognosis group were lower than those in poor prognosis group,and the level of Fib was higher than that in poor prognosis group（P<0.05）. Conclusions The levels of coagulation function,serum CRP and Tau protein are abnormal in patients with brain injury,and the above indicators were related to the degree of disease and prognosis,which can be used for disease diagnosis and disease monitoring.

Key words: Brain injury, Coagulation function, C-reactive protein, Tau protein, Prognosis