Clinical role of serum ICTP and MMP-2 in acute myocardial infarction

doi:10.3969/j.issn.1673-8640.2020.12.016

Abstract

Abstract:

Objective To investigate the clinical role of serum matrix metalloprotein（MMP）-2 and typeⅠcollagen carboxyl terminal peptide（ICTP） in acute myocardial infarction（AMI）. Methods Totally,120 patients with AMI were enrolled,and they were classified into mild group（Gensini score 0-7,36 cases）,moderate group（Gensini score 8-14,54 cases）,severe group（Gensini score 14,30 cases）,and 120 healthy subjects were enrolled as healthy control group. The general data and laboratory determination results,including sex,age,body mass index（BMI）,smoking history,mean arterial pressure（MAP）,low-density lipoprotein cholesterol（LDL-C）,triglyceride（TG）,etc.,were collected. The hypertension history,diabetes mellitus history,Gensini score and cardiac troponin T（cTnT） results of AMI patients were collected. The serum levels of ICTP and MMP-2 were determined. Results There was no statistical significance in the general data（sex,age,BMI,MAP,LDL-C,TG and smoking history） between healthy control group and AMI group（P>0.05）. The levels of serum ICTP and MMP-2 in AMI group were higher than those in healthy control group（P<0.001）. The results of ROC curve analysis showed that the areas under curves（AUC） of ICTP and MMP-2 were 0.862 and 0.887,the optimal cut-off values were 6.4 and 3.6 ng/mL,the sensitivities were 81.67% and 85.00%,the specificities were 83.33% and 83.33%,respectively. The AUC of ICTP combined with MMP-2 was 0.978,the sensitivity was 96.67%,and the specificity was 95.00%. The Gensini score and serum cTnT,ICTP,MMP-2 levels of mild stenosis group,moderate stenosis group and severe stenosis group were increased in turn,and there was statistical significance among the 3 groups（P<0.05）,but there was no statistical significance in the other indexes between the 2 groups（P>0.05）. Pearson correlation analysis showed that serum ICTP and MMP-2 were positively correlated with Gensini score（r=0.862 and 0.858,P<0.001）. Conclusions Serum ICTP and MMP-2 play roles in AMI,which can be used for AMI diagnosis and condition evaluation.

Key words: Matrix metalloprotein-2, TypeⅠcollagen carboxyl terminal peptide, Acute myocardial infarction, Coronary artery disease

CLC Number:

R446.1

LI Ying, CAI Qin, ZHANG Weiwei, WANG Baoli, LI Chenhui. Clinical role of serum ICTP and MMP-2 in acute myocardial infarction[J]. Laboratory Medicine, 2020, 35(12): 1272-1276.

Figures/Tables 5

References 20

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组别	例数	性别		年龄/岁	BMI/ （kg/m²）	MAP/ kPa	LDL-C/（mmol/L）	TG/ （mmol/L）	吸烟史/ 例（%）
组别	例数	男/例	女/例	年龄/岁	BMI/ （kg/m²）	MAP/ kPa	LDL-C/（mmol/L）	TG/ （mmol/L）	吸烟史/ 例（%）
正常对照组	120	68	52	57.20±6.58	24.32±3.05	13.62±1.49	4.47±0.51	2.02±0.32	20（16.67）
AMI组	120	64	56	57.82±6.61	24.57±3.04	13.73±1.52	4.50±0.53	2.04±0.34	24（20.00）
统计值		0.269		0.728	0.636	0.566	0.447	0.469	0.445
P值		0.604		0.467	0.525	0.572	0.655	0.639	0.505

组别	例数	性别		年龄/岁	BMI/ （kg/m²）	MAP/ kPa	LDL-C/（mmol/L）	TG/ （mmol/L）	吸烟史/ 例（%）
组别	例数	男/例	女/例	年龄/岁	BMI/ （kg/m²）	MAP/ kPa	LDL-C/（mmol/L）	TG/ （mmol/L）	吸烟史/ 例（%）
正常对照组	120	68	52	57.20±6.58	24.32±3.05	13.62±1.49	4.47±0.51	2.02±0.32	20（16.67）
AMI组	120	64	56	57.82±6.61	24.57±3.04	13.73±1.52	4.50±0.53	2.04±0.34	24（20.00）
统计值		0.269		0.728	0.636	0.566	0.447	0.469	0.445
P值		0.604		0.467	0.525	0.572	0.655	0.639	0.505

组别	例数	性别			年龄/岁	BMI/ （kg/m²）		MAP/ kPa		TG/ （mmol/L）		LDL-C/ （mmol/L）	cTnT/ （μg/L）
组别	例数	男/例	女/例		年龄/岁	BMI/ （kg/m²）		MAP/ kPa		TG/ （mmol/L）		LDL-C/ （mmol/L）	cTnT/ （μg/L）
轻度狭窄组	36	20	16		57.56±6.72	24.36±3.42		13.70±1.55		2.03±0.36		4.48±0.55	0.94±0.16
中度狭窄组	54	28	26		57.80±6.76	24.56±3.15		13.73±1.57		2.03±0.36		4.50±0.56	1.32±0.18
重度狭窄组	30	16	14		58.21±6.78	24.73±3.25		1.77±1.55		2.07±0.38		4.53±0.54	1.63±0.21
统计值		0.752			0.621	0.507		1.362		0.682		0.881	34.527
P值		0.486			0.435	0.589		0.174		0.402		0.295	<0.001
组别	吸烟/例（%）			Gensini评分/分			高血压/例（%）		糖尿病/例（%）		ICTP/（ng/mL）		MMP-2/（ng/mL）
轻度狭窄组	6（16.67）			5.03±0.72			10（27.78）		6（16.67）		6.26±0.72		4.12±0.46
中度狭窄组	10（18.52）			10.24±1.22^*			16（29.63）		8（14.81）		9.20±1.36^*		5.59±0.66^*
重度狭窄组	8（26.67）			20.37±2.05^*#			12（40.00）		6（20.00）		12.38±1.58^*#		7.08±0.79^*#
统计值	0.962			18.621			0.842		0.902		19.651		16.352
P值	0.252			<0.001			0.319		0.281		<0.001		<0.001

组别	例数	性别			年龄/岁	BMI/ （kg/m²）		MAP/ kPa		TG/ （mmol/L）		LDL-C/ （mmol/L）	cTnT/ （μg/L）
组别	例数	男/例	女/例		年龄/岁	BMI/ （kg/m²）		MAP/ kPa		TG/ （mmol/L）		LDL-C/ （mmol/L）	cTnT/ （μg/L）
轻度狭窄组	36	20	16		57.56±6.72	24.36±3.42		13.70±1.55		2.03±0.36		4.48±0.55	0.94±0.16
中度狭窄组	54	28	26		57.80±6.76	24.56±3.15		13.73±1.57		2.03±0.36		4.50±0.56	1.32±0.18
重度狭窄组	30	16	14		58.21±6.78	24.73±3.25		1.77±1.55		2.07±0.38		4.53±0.54	1.63±0.21
统计值		0.752			0.621	0.507		1.362		0.682		0.881	34.527
P值		0.486			0.435	0.589		0.174		0.402		0.295	<0.001
组别	吸烟/例（%）			Gensini评分/分			高血压/例（%）		糖尿病/例（%）		ICTP/（ng/mL）		MMP-2/（ng/mL）
轻度狭窄组	6（16.67）			5.03±0.72			10（27.78）		6（16.67）		6.26±0.72		4.12±0.46
中度狭窄组	10（18.52）			10.24±1.22^*			16（29.63）		8（14.81）		9.20±1.36^*		5.59±0.66^*
重度狭窄组	8（26.67）			20.37±2.05^*#			12（40.00）		6（20.00）		12.38±1.58^*#		7.08±0.79^*#
统计值	0.962			18.621			0.842		0.902		19.651		16.352
P值	0.252			<0.001			0.319		0.281		<0.001		<0.001